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首页> 外文期刊>The European Journal of Neuroscience >Muscarinic blockade weakens interaction of gamma with theta rhythms in mouse hippocampus
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Muscarinic blockade weakens interaction of gamma with theta rhythms in mouse hippocampus

机译：毒蕈碱阻滞减弱小鼠海马中γ与θ节奏的相互作用

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9 (4-12 Hz) and y (40-90) oscillations are prominent rhythms in the mammalian brain. A striking feature of these rhythms, possibly vital to memory encoding, is their specific coordination in a manner that has been termed 'nesting', i.e. the preferred occurrence of bouts of y activity during specific phases of θ. Both rhythms are shaped by the neuromodulator acetylcholine, but it is unknown to what degree their coordination is influenced by cholinergic neuromodulation. Here, we investigated the effects of a blockade of muscarinic acetylcholine receptors by atropine on θ and y oscillations, and their interaction, in mouse hippocampus in vivo. Multi-site recordings from area CA1 of freely moving mice showed that under control conditions y activity was amplitude-modulated at θ frequencies. This coordination of θ and y oscillations, as assessed by cross-correlation of θ with the y envelope, was prominent in basal and apical dendritic laminae but not in intermediate laminae. It was stronger during active exploration than during awake immobility. Atropine (50 mg/kg intraperitoneal) altered several aspects of the individual and nested rhythms. It rendered 9 activity irregular, decreased θ oscillation frequency and reduced y power. Atropine also reduced the amplitude-modulation of y oscillations at 9 frequencies, in part by perturbing the coordination of the rhythms on a short time scale. Thus, our findings demonstrate that phase locking of the amplitude of gamma oscillations to θ in hippocampal area CA1 is partially governed by neuronal elements harbouring muscarinic receptors.
机译：9（4-12 Hz）和y（40-90）振荡是哺乳动物大脑中重要的节律。这些节奏的显着特征（可能对记忆编码至关重要）是以特定的协调方式进行的，这些方式已被称为“嵌套”，即在特定的θ阶段出现y活动的优先回合。这两种节律都由神经调节剂乙酰胆碱决定，但尚不清楚它们的协调作用在多大程度上受胆碱能神经调节的影响。在这里，我们研究了在小鼠海马体内，阿托品对毒蕈碱乙酰胆碱受体的阻滞作用对θ和y振荡及其相互作用的影响。自由移动的小鼠区域CA1的多站点记录显示，在控制条件下，y活动在θ频率处受到幅度调制。通过θ与y包络的互相关评估，这种θ和y振荡的协调在基底和顶端树突层中很明显，而在中间层中则不明显。在主动勘探过程中，它比在清醒状态下不动时要强。阿托品（50 mg / kg腹膜内）改变了个体和嵌套节律的几个方面。它使9个活动不规则，降低了θ振荡频率，并降低了y功率。阿托品还降低了9个频率下y振荡的幅度调制，部分原因是在较短的时间尺度上扰动了节奏的协调性。因此，我们的发现表明，在海马区CA1中，伽马振荡的幅度到θ的相位锁定部分由具有毒蕈碱受体的神经元控制。

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