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首页> 外文期刊>The European Journal of Neuroscience >Axonal projections of single auditory neurons in the thalamic reticular nucleus: implications for tonotopy-related gating function and cross-modal modulation.
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Axonal projections of single auditory neurons in the thalamic reticular nucleus: implications for tonotopy-related gating function and cross-modal modulation.

机译：丘脑网状核中单个听觉神经元的轴突投影：对与拓朴相关的门控功能和交叉模式调节的影响。

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摘要

Tonotopically comparable subfields of the primary auditory area (AI) and nonprimary auditory areas (non-AI), i.e. posterodorsal area (PD) and ventral auditory area (VA), in the rat cortex have similar topographies in the projection to the ventral division of the medial geniculate nucleus (MGV), but reverse topographies in the projection to the thalamic reticular nucleus (TRN). In this study, we examined axonal projections of single auditory TRN cells, using juxtacellular recording and labeling techniques, to determine features of TRN projections and estimate how the TRN mediates corticofugal inhibition along with the reverse topographies of cortical projections to the TRN. Auditory TRN cells sent topographic projections to limited parts of the MGV in a manner that relays cortical inputs from tonotopically comparable subfields of the AI and non-AI (PD and VA) to different parts of the MGV. The results suggest that corticofugal excitations from the AI and non-AI modulate thalamic cell activity in the same part of the MGV, whereas corticofugal inhibitions via the TRN modulate cell activity in different parts of the MGV with regard to tonotopic organization. The AI and non-AI could serve distinctive gating functions for auditory attention through the differential topography of inhibitory modulation. In addition, we obtained an intriguing finding that a subset of auditory TRN cells projected to the somatosensory but not to the auditory thalamic nuclei. There was also a cell projecting to the MGV and somatosensory nuclei. These findings extend the previously suggested possibility that TRN has a cross-modal as well as an intramodal gating function in the thalamus.
机译：大鼠皮层的主要听觉区域（AI）和非主要听觉区域（non-AI）的同位异位子区域在大鼠皮层的投影中具有相似的形貌，即大鼠皮层的后嗅区域（PD）和腹侧听觉区域（VA）。内侧膝状核（MGV），但向丘脑网状核（TRN）投影时的形貌反转。在这项研究中，我们检查了单个听觉TRN细胞的轴突投影，使用近细胞记录和标记技术来确定TRN投影的特征，并估计TRN如何介导皮质淋巴管抑制以及皮质投影向TRN的反向拓扑。听觉TRN细胞将地形投影发送到MGV的有限部分，其方式是将来自AI和非AI（PD和VA）的同位异位子场的皮质输入传递到MGV的不同部分。结果表明，来自AI和非AI的皮质ugal激发可调节MGV相同部位的丘脑细胞活性，而通过TRN抑制皮质ug的兴奋性则可调节MGV不同部位的丘脑细胞活性。 AI和非AI可以通过抑制性调制的不同地形来发挥独特的门控功能，引起听觉注意。此外，我们获得了一个有趣的发现，即听觉TRN细胞的一个子集投射到体感而不是听觉丘脑核。也有一个细胞投射到MGV和体感核。这些发现扩展了先前提出的可能性，即TRN在丘脑中具有交叉模式以及内部模式的门控功能。

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