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首页> 外文期刊>The European Journal of Neuroscience >Lesions of rat infralimbic cortex result in disrupted retardation but normal summation test performance following training on a Pavlovian conditioned inhibition procedure.
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Lesions of rat infralimbic cortex result in disrupted retardation but normal summation test performance following training on a Pavlovian conditioned inhibition procedure.

机译:在巴甫洛夫病条件抑制程序上训练后,大鼠下肢皮质皮损会导致延迟受阻,但正常的总和测试性能。

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摘要

The prefrontal cortex has a well-established role in the inhibition of inappropriate responding. Converging evidence implicates the infralimbic (IL) region of the rat medial prefrontal cortex (MPFC) in the maintenance of extinction [Quirk et al. (2000)J. Neurosci., 20, 6225-6231; Rhodes & Killcross (2004)Learn. Mem., 11, 611-616], a process generally considered to be mediated by the formation of inhibitory associations. An appetitive Pavlovian conditioned inhibition paradigm was used in order to investigate further the role of the IL MPFC in the control over behaviour by inhibitory associations. In two separate experiments, the effect of IL lesions on summation and retardation tests of conditioned inhibition was assessed. IL lesions did not affect summation test performance, indicating that lesioned animals were able to acquire inhibitory associations between a stimulus and reward and could express them normally when placed in competition with an excitatory cue. However, the retardation of excitatory conditioning that is normally seen when a stimulus with inhibitory properties is subsequently paired with reward was abolished in IL-lesioned animals. This suggests a selective role for the IL MPFC in the competition for behavioural control between the inhibitory and excitatory associations of a single stimulus.
机译:前额叶皮层在抑制不适当的反应中具有公认的作用。越来越多的证据暗示大鼠内侧前额叶皮层(MPFC)的下缘(IL)区域维持了灭绝[Quirk等。 (2000)J.神经科学杂志,20,6225-6231; Rhodes&Killcross(2004)学习。 Mem。,11,611-616],通常被认为是抑制性缔合的介导过程。为了研究IL MPFC在通过抑制性关联控制行为中的作用,使用了具有竞争性的巴甫洛夫条件式抑制范例。在两个单独的实验中,评估了IL病变对条件抑制的总和和延迟测试的影响。 IL损伤不影响总和测试性能,表明患病的动物能够获得刺激和奖赏之间的抑制性关联,并且在与兴奋性提示竞争时能够正常表达它们。然而,在IL损伤的动物中消除了通常在具有抑制性质的刺激与奖励配对时通常看到的兴奋性调节的延迟。这表明IL MPFC在单个刺激的抑制性和兴奋性结合之间的行为控制竞争中具有选择性作用。

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