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首页> 外文期刊>The European Journal of Neuroscience >Continuous white noise exposure during and after auditory critical period differentially alters bidirectional thalamocortical plasticity in rat auditory cortex in vivo.
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Continuous white noise exposure during and after auditory critical period differentially alters bidirectional thalamocortical plasticity in rat auditory cortex in vivo.

机译：在听觉关键期期间和之后持续的白噪声暴露有差别地改变了体内大鼠听觉皮层的双向丘脑可塑性。

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摘要

Long-term potentiation (LTP) and long-term depression are thought to mediate activity-dependent brain plasticity but their role in the development of the thalamocortical auditory system in vivo has not been investigated. In adult urethane-anaesthetized rats, theta-burst stimulation of the medial geniculate nucleus produced robust LTP (40% amplitude enhancement) of field post-synaptic evoked potentials recorded in the superficial layers of the primary auditory cortex. Low-frequency (1-Hz) stimulation resulted in transient depression ( approximately 40%) of field post-synaptic evoked potential amplitude. Both LTP and synaptic depression were found to be dependent on cortical N-methyl-d-aspartate receptors. Thalamocortical plasticity was also assessed after continuous white noise exposure, thought to arrest auditory cortex maturation when applied during the critical period of post-natal primary auditory cortex development. Rats housed in continuous white noise for the first 50 days of post-natal life exhibited greater LTP ( approximately 80%) than controls reared in unaltered acoustic environments. The protocol used to elicit depression also resulted in substantial LTP ( approximately 50%) in white noise-reared animals. Adults housed in white noise for the same length of time exhibited normal LTP but displayed greater and persistent levels of synaptic depression ( approximately 70%). Thus, the absence of patterned auditory stimulation during early post-natal life appears to retard sensory-dependent thalamocortical synaptic strengthening, as indicated by the preferential readiness for synaptic potentiation over depression. The fact that the same auditory manipulation in adults results in synapses favouring depression demonstrates the critical role of developmental stage in determining the direction of synaptic modification in the thalamocortical auditory system.
机译：长期增强（LTP）和长期抑郁被认为可以调节活动依赖的大脑可塑性，但尚未研究它们在体内丘脑皮质听觉系统发育中的作用。在成年氨基甲酸乙酯麻醉的大鼠中，内侧膝状中枢核的theta-burst刺激产生了在初级听觉皮层表层记录的突触后诱发电位的强大LTP（幅度提高40％）。低频（1-Hz）刺激导致突触后诱发电位场的瞬时降低（约40％）。发现LTP和突触抑制均依赖于皮质N-甲基-d-天冬氨酸受体。连续暴露于白噪声后，还评估了丘脑皮层的可塑性，认为当在产后初级听觉皮层发育的关键时期使用时，可阻止听觉皮层的成熟。出生后头50天内饲养在连续白噪声中的大鼠，其LTP（在未改变声学环境下饲养的对照组）表现出更大的LTP（约80％）。用于诱发抑郁的方案在引起白噪声的动物中也导致大量的LTP（约50％）。居住在相同时间的白噪声中的成年人表现出正常的LTP，但显示出更高且持续的突触抑制水平（约70％）。因此，在出生后的早期生活中缺乏模式性听觉刺激似乎会阻碍感觉依赖性丘脑突触的增强，这是由突触增强作用比抑郁症的优先准备所表明的。在成年人中相同的听觉操纵导致突触有利于抑郁的事实表明，发育阶段在确定丘脑皮质听觉系统中突触修饰的方向中起着至关重要的作用。

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