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首页> 外文期刊>The European Journal of Neuroscience >Changes in nucleus accumbens dopamine transmission associated with fixed- and variable-time schedule-induced feeding.
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Changes in nucleus accumbens dopamine transmission associated with fixed- and variable-time schedule-induced feeding.

机译：伏伏核多巴胺传递的变化与固定和可变时间的日程诱导的进食有关。

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We examined the changes in nucleus accumbens (NAcc) dopamine (DA) transmission associated with non-contingent meal presentations under conditions of high (fixed time-, FT-schedule) and low (variable time-, VT-schedule) predictability. Of interest were the changes in NAcc DA transmission associated with discrepancies between the time food is expected and when it is actually presented. We used in vivo voltammetry to monitor NAcc DA levels as rats received, on the first and second test days, 30-s meals of condensed milk on a VT-52 schedule (inter-meal intervals of 32, 35, 40, 45, 52, 64, and 95 s). On the third and subsequent days meals were presented first on a VT-52 s schedule and then on an FT-52 s schedule. On day 1, monotonic increases in NAcc DA signals were observed during both meal consumption and the intervals between VT meal presentations. By day 2, however, meal presentations on the VT schedule elicited biphasic DA signal fluctuations; DA signals increased prior to each meal presentation but then started to decline during the feeding bout that followed. Fixed-time meal presentations on day 3 disrupted this pattern, resulting in a concurrent escalation of DA signal fluctuations upon subsequent VT meal presentations. These findings provide further evidence that, in trained animals, NAcc DA transmission is activated by conditioned incentive cues rather than by primary rewards. They also suggest that the increases in NAcc DA transmission associated with reward expectancy are sensitive to temporal cues (e.g. interval timing) and to discrepancies between expected and actual outcomes.
机译：我们检查了在高（固定时间，FT时间表）和低（可变时间，VT时间表）可预测性条件下，伏隔核（NAcc）多巴胺（DA）传递与非特异进餐表现相关的变化。令人感兴趣的是，NAcc DA传播的变化与预期食物的时间和实际提供食物之间的差异有关。当大鼠在测试的第一天和第二天以VT-52计划进餐30 s炼乳时，我们使用体内伏安法监测NAcc DA水平（进餐间隔为32、35、40、45、52 ，64和95秒）。在第三天及以后的几天中，首先按VT-52的时间表提供膳食，然后按FT-52的时间表提供膳食。在第1天，在进餐量和VT进餐间隔之间观察到NAcc DA信号单调增加。然而，到第2天，VT时间表上的进餐提示引起了双相DA信号波动;每次进餐前DA信号增加，但随后的喂食回潮开始下降。第3天的固定时间进餐演示破坏了这种模式，导致随后的VT进餐演示同时导致DA信号波动的同时升级。这些发现提供了进一步的证据，在受过训练的动物中，NAcc DA的传播是由条件性激励线索而不是主要奖励所激活的。他们还建议，与预期报酬相关的NAcc DA传递的增加对时间线索（例如间隔时间）以及预期结果与实际结果之间的差异敏感。

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