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首页> 外文期刊>The European Journal of Neuroscience >Cumulative sessions of repetitive transcranial magnetic stimulation (rTMS) build up facilitation to subsequent TMS-mediated behavioural disruptions.
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Cumulative sessions of repetitive transcranial magnetic stimulation (rTMS) build up facilitation to subsequent TMS-mediated behavioural disruptions.

机译：反复经颅磁刺激（rTMS）的累积过程促进了随后TMS介导的行为中断的促进。

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A single session of repetitive transcranial magnetic stimulation (rTMS) can induce behavioural effects that outlast the duration of the stimulation train itself (off-line effects). Series of rTMS sessions on consecutive days are being used for therapeutic applications in a variety of disorders and are assumed to lead to the build-up of cumulative effects. However, no studies have carefully assessed this notion. In the present study we applied 30 daily sessions of 1 Hz rTMS (continuous train of 20 min) to repeatedly modulate activity in the posterior parietal cortex and associated neural systems in two intact cats. We assessed the effect on visuospatial orientation before and after each stimulation session. Cumulative sessions of rTMS progressively induced visuospatial neglect-like 'after-effects' of greater magnitude (from 5-10% to 40-50% error levels) and increasing spatial extent (from 90-75 degrees to 45-30 degrees eccentricity locations), affecting the visual hemifield contralateral to the stimulated hemisphere. Nonetheless, 60 min after each TMS session, visual detection-localization abilities repeatedly returned to baseline levels. Furthermore, no lasting behavioural effect could be demonstrated at any time across the study, when subjects were tested 1 or 24 h post-rTMS. We conclude that the past history of periodically cumulative rTMS sessions builds up a lasting 'memory', resulting in increased facilitation to subsequent TMS-induced disruptions. Such a phenomenon allows a behavioural effect of progressively higher magnitude, but equal duration, in response to individual TMS interventions.
机译：单次重复经颅磁刺激（rTMS）可以诱发行为效应，这种行为效应会超过刺激序列本身的持续时间（脱机效应）。连续几天的一系列rTMS疗程被用于各种疾病的治疗应用，并被认为会导致累积效应的累积。但是，尚无研究仔细评估此概念。在本研究中，我们每天进行30次1 Hz rTMS（20分钟的连续训练），以重复调节两只完整猫的顶叶后皮质和相关神经系统的活动。我们评估了每次刺激之前和之后对视觉空间取向的影响。 rTMS的累积会话逐渐诱发更大程度的视觉空间忽略样的“后效应”（从5-10％到40-50％的误差水平）并增加空间范围（从90-75度到45-30度的偏心度位置） ，影响受刺激的半球对侧的视觉半场。但是，在每次TMS会话后60分钟，视觉检测定位功能都反复返回到基线水平。此外，在rTMS后1或24小时对受试者进行测试时，在整个研究中的任何时间都无法显示出持久的行为效果。我们得出的结论是，过去定期累积rTMS会话的历史建立了持久的“记忆”，从而增加了对随后TMS引起的中断的促进。这种现象允许对个别TMS干预做出反应，其行为效果逐渐增强，但持续时间相等。

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