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首页> 外文期刊>The European Journal of Neuroscience >Opening of the blood-brain barrier during isoflurane anaesthesia.
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Opening of the blood-brain barrier during isoflurane anaesthesia.

机译：异氟烷麻醉期间血脑屏障的打开。

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摘要

In order to produce its desired effect, anaesthesia acts upon neuronal elements by modifying membrane conductances and transmitter interactions. The effect of higher doses of isoflurane, widely used in clinical settings, on the permeability of the blood-brain barrier (BBB) is meanwhile ignored. In this study we investigated the integrity of the BBB during various levels of isoflurane anaesthesia (1% and 3%) in cats by monitoring the extravasation of Evans blue. Simultaneously we measured the electroencephalogram (EEG), with particular emphasis on its direct current (DC) component. High doses of anaesthetic (3%) broke down the BBB in the cortex and thalamus, while milder doses (1%) only opened the BBB in the thalamus. The fluorescent signal of Evans blue was visible over an extravascular length of 23 mum in the cortex and 25 mum in the thalamus, similar to the diffusion of the same dye when the BBB was disrupted with mannitol. The opening of the BBB was associated with (i) a positive DC shift in the EEGmeasured on the scalp and (ii) an evaluated increase in cerebral volume of 2-2.8%. The opening of the BBB by high doses of isoflurane brings into discussion hitherto unexplored effects of anaesthesia on the brain. The electrophysiological correlate provided by the DC component of the EEG constitutes a promising option for the assessment of the BBB integrity during human anaesthesia.
机译：为了产生所需的效果，麻醉通过改变膜电导和递质相互作用来作用于神经元。同时，临床上广泛使用的高剂量异氟烷对血脑屏障（BBB）渗透性的影响被忽略。在这项研究中，我们通过监测伊文思蓝的外渗，研究了不同水平的异氟醚麻醉（分别为1％和3％）中的BBB的完整性。同时，我们测量了脑电图（EEG），并特别强调了其直流（DC）分量。高剂量的麻醉剂（3％）使皮层和丘脑中的血脑屏障破裂，而轻度的麻醉剂（1％）仅使丘脑中的血脑屏障开放。在皮质外23毫米和丘脑内25毫米的血管外长度上，可以看到伊文思蓝的荧光信号，类似于当BBB被甘露醇破坏时，同一染料的扩散。 BBB的开放与（i）在头皮上测得的脑电图的正DC移位和（ii）评估的脑容量增加了2-2.8％有关。高剂量异氟烷打开血脑屏障至今仍未引起人们对麻醉脑的探索作用的讨论。由EEG的DC成分提供的电生理相关因素构成了在人体麻醉过程中评估BBB完整性的有前途的选择。

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