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首页> 外文期刊>The European Journal of Neuroscience >Suppression of activity in the forelimb motor cortex temporarily enlarges forelimb representation in the homotopic cortex in adult rats.
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Suppression of activity in the forelimb motor cortex temporarily enlarges forelimb representation in the homotopic cortex in adult rats.

机译：成年大鼠前肢运动皮层活动的抑制暂时扩大了同位皮层中前肢的代表。

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After forelimb motor cortex (FMC) damage, the unaffected homotopic motor cortex showed plastic changes. The present experiments were designed to clarify the electrophysiological nature of these interhemispheric effects. To this end, the output reorganization of the FMC was investigated after homotopic area activity was suppressed in adult rats. FMC output was compared after lidocaine-induced inactivation (L-group) or quinolinic acid-induced lesion (Q-group) of the contralateral homotopic cortex. In the Q-group of animals, FMC mapping was performed, respectively, 3 days (Q3D group) and 2 weeks (Q2W group) after cortical lesion. In each animal, FMC output was assessed by mapping movements induced by intracortical microstimulation (ICMS) in both hemispheres (hemisphere ipsilateral and contralateral to injections). The findings demonstrated that in the L-group, the size of forelimb representation was 42.2% higher than in the control group (P < 0.0001). The percentage of dual forelimb-vibrissa movement sites significantly increased over the controls (P < 0.0005). The dual-movement sites occupied a strip of the map along the rostrocaudal border between the forelimb and vibrissa representations. This form of interhemispheric diaschisis had completely reversed, with the recovery of the baseline map, 3 days after the lesion in the contralateral FMC. This restored forelimb map showed no ICMS-induced changes 2 weeks after the lesion in the contralateral FMC. The present results suggest that the FMCs in the two hemispheres interact continuously through predominantly inhibitory influences that preserve the forelimb representation and the border vs. vibrissa representation.
机译：前肢运动皮层（FMC）受损后，未受影响的同位运动皮层显示出塑性变化。本实验旨在阐明这些半球间效应的电生理特性。为此，在成年大鼠的同位面积活性被抑制后，研究了FMC的输出重组。比较利多卡因诱导的对侧皮质皮层失活（L组）或喹啉酸引起的病变（Q组）后的FMC输出。在Q组动物中，分别在皮质病变后3天（Q3D组）和2周（Q2W组）进行FMC绘图。在每只动物中，通过绘制皮层内微刺激（ICMS）在两个半球（注射的同侧和对侧的半球）诱导的运动作图来评估FMC的输出。研究结果表明，在L组中，前肢表现的大小比对照组高42.2％（P <0.0001）。双前肢触须运动部位的百分比明显高于对照组（P <0.0005）。双向运动的位置沿着前肢和触须表示之间的后尾骨边界占据了地图的一条带。对侧FMC病变后3天，这种半球间透析形式已完全逆转，基线图已恢复。该恢复的前肢图显示对侧FMC病变后2周没有ICMS引起的变化。目前的结果表明，两个半球中的FMC通过主要抑制性作用连续相互作用，这些抑制性作用保留了前肢的表现以及边界与触须的表现。

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