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首页> 外文期刊>The European Journal of Neuroscience >A circulating ghrelin mimetic attenuates light-induced phase delay of mice and light-induced Fos expression in the suprachiasmatic nucleus of rats.
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A circulating ghrelin mimetic attenuates light-induced phase delay of mice and light-induced Fos expression in the suprachiasmatic nucleus of rats.

机译：循环生长素释放肽模拟物减弱了小鼠的光诱导的相位延迟和光诱导的大鼠视交叉上核中的Fos表达。

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摘要

Anatomical evidence suggests that the ventromedial arcuate nucleus (vmARC) is a route for circulating hormonal communications to the suprachiasmatic nucleus (SCN). Whether this vmARC-SCN connection is involved in the modulation of circadian activity of the SCN is not yet known. We recently demonstrated, in rats, that intravenous (i.v.) injection of a ghrelin mimetic, GHRP-6, during the daytime activated neurons in the vmARC and reduced the normal endogenous daytime Fos expression in the SCN. In the present study we show that i.v. administration of GHRP-6 decreases light-induced Fos expression at ZT13 in the rat SCN by 50%, indicating that light-induced changes in the SCN Fos expression can also be reduced by GHRP-6. Because it is difficult to study light-induced phase changes in rats, we examined the functional effects of GHRP-6 on light-induced phase shifts in mice and demonstrated that peripherally injected GHRP-6 attenuates light-induced phase delays at ZT13 by 45%. However, light-induced Fos expression in the mice SCN was not blocked by GHRP-6. These results illustrate that acute stimulation of the ghrelinergic system may modulate SCN activity, but that its effect on light-induced phase shifts and Fos expression in the SCN might be species related.
机译：解剖学证据表明，腹侧弓状核（vmARC）是循环激素传递至视交叉上核（SCN）的途径。尚不清楚此vmARC-SCN连接是否参与SCN的昼夜活动的调节。我们最近在大鼠中证明，白天在vmARC中激活的神经元静脉内（i.v.）注射生长素释放肽模拟物GHRP-6，并降低了SCN中正常的内源性白天Fos表达。在本研究中，我们表明施用GHRP-6可使大鼠SCN中ZT13处的光诱导的Fos表达降低50％，这表明GHRP-6也可以降低SCN Fos表达的光诱导变化。因为很难研究大鼠的光诱导相变，所以我们检查了GHRP-6对小鼠光诱导相移的功能影响，并证明了外围注射的GHRP-6将ZT13处的光诱导相延迟衰减了45％。 。然而，GHRP-6并未阻断小鼠SCN中光诱导的Fos表达。这些结果表明，对生长激素释放酶系统的急性刺激可能会调节SCN的活性，但其对光诱导的相移和SCN中Fos表达的影响可能与物种有关。

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