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首页> 外文期刊>The European Journal of Neuroscience >Changes in hippocampal function of ovariectomized rats after sequential low doses of estradiol to simulate the preovulatory estrogen surge.
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Changes in hippocampal function of ovariectomized rats after sequential low doses of estradiol to simulate the preovulatory estrogen surge.

机译：连续低剂量雌二醇模拟排卵前雌激素激增后，去卵巢大鼠海马功能的变化。

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In adult female rats, robust hippocampal changes occur when estradiol rises on the morning of proestrus. Whether estradiol mediates these changes, however, remains unknown. To address this issue, we used sequential injections of estradiol to simulate two key components of the preovulatory surge: the rapid rise in estradiol on proestrous morning, and the slower rise during the preceding day, diestrus 2. Animals were examined mid-morning of simulated proestrus, and compared to vehicle-treated or intact rats. In both simulated and intact rats, CA1-evoked responses were potentiated in hippocampal slices, and presynaptic mechanisms appeared to contribute. In CA3, multiple population spikes were evoked in response to mossy fiber stimuli, and expression of brain-derived neurotrophic factor was increased. Simulation of proestrous morning also improved performance on object and place recognition tests, in comparison to vehicle treatment. Surprisingly, effects on CA1-evoked responses showed a dependence on estradiol during simulated diestrus 2, as well as a dependence on proestrous morning. Increasing estradiol above the physiological range on proestrous morning paradoxically decreased evoked responses in CA1. However, CA3 pyramidal cell activity increased further, and became synchronized. Together, the results confirm that physiological estradiol levels are sufficient to profoundly affect hippocampal function. In addition: (i) changes on proestrous morning appear to depend on slow increases in estradiol during the preceding day; (ii) effects are extremely sensitive to the peak serum level on proestrous morning; and (iii) there are striking subfield differences within the hippocampus.
机译：在成年雌性大鼠中，当雌二醇在发情前期早晨升高时，海马发生强烈变化。然而，雌二醇是否介导这些变化尚不清楚。为了解决这个问题，我们使用雌二醇的顺序注射来模拟排卵前期潮气的两个关键组成部分：雌激素在发情前期的快速上升和前一天的缓慢增长，即雌激素2。发情，并与经媒介物处理或完整的大鼠进行比较。在模拟和完整大鼠中，CA1诱发的反应在海马切片中均得到增强，并且突触前机制似乎起作用。在CA3中，响应长满苔藓的纤维刺激引起多个种群高峰，并且脑源性神经营养因子的表达增加。与车辆处理相比，模拟早晨发情还改善了对象和位置识别测试的性能。出乎意料的是，对CA1诱发的反应的影响显示出在模拟的二重音2期间对雌二醇的依赖性以及对早孕的依赖性。在早孕期将雌二醇增加到生理范围之上，这自相矛盾地降低了CA1引起的诱发反应。但是，CA3锥体细胞活性进一步增加，并变得同步。在一起，结果证实生理雌二醇水平足以深刻影响海马功能。此外：（i）早晨发情的变化似乎取决于前一天雌二醇的缓慢增加; （ii）在发情的早晨，这种影响对血清峰值水平极为敏感; （iii）海马内部存在明显的亚场差异。

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