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首页> 外文期刊>The European Journal of Neuroscience >Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis.
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Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis.

机译：2型促肾上腺皮质激素释放因子受体在控制小鼠食物摄入中的作用：进餐模式分析。

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摘要

The actions of corticotropin-releasing factor (CRF) and related peptides are mediated by two receptors (CRF(1) and CRF(2)). The respective role of each subtype in the control of food intake remains poorly known. In the present study, we examined the quantity and microstructure of ingestive behavior of knockout (KO) mice lacking CRF(2) receptors and their wild-type (WT) littermates. Under basal conditions, CRF(2) KO mice showed increased nocturnal food intake, evident as an increased zenith in circadian cosinor analysis of food intake. Microstructure analysis revealed that this greater food intake reflected increased meal size, rather than meal frequency, suggesting a decreased satiating value of food. Following acute restraint stress, CRF(2) KO mice showed an intact immediate anorectic response with increased latency to eat and decreased meal size. However, CRF(2) deletion abolished the prolonged phase of restraint-induced anorexia. CRF(2) KO mice did not differ from WT controls in feeding responses tofood deprivation or injection of ghrelin receptor agonists. Independent of genotype, food deprivation increased food intake, with dramatic changes in meal size, meal frequency, water : food ratio and eating rate. Acyl-ghrelin or BIM-28131, a potent ghrelin analog, dose-dependently stimulated food intake by increasing meal size (ghrelin, BIM-28131) and meal number (BIM-28131), while slowing the average eating rate (BIM-28131) similarly in WT and KO mice. These results suggest that the CRF(2) receptor is involved in the control of meal size during the active phase of eating and following acute exposure to stress.
机译：促肾上腺皮质激素释放因子（CRF）和相关肽的作用由两个受体（CRF（1）和CRF（2））介导。每种亚型在控制食物摄入中的各自作用仍然知之甚少。在本研究中，我们检查了缺乏CRF（2）受体及其野生型（WT）同窝仔的基因敲除（KO）小鼠的摄食行为的数​​量和微观结构。在基础条件下，CRF（2）KO小鼠的夜间食物摄入量增加，在昼夜节食食物摄入量分析中，天顶增加。微观结构分析表明，食物摄入量的增加反映了进餐量的增加，而不是进餐频率的增加，表明食物的饱腹感降低。急性约束压力后，CRF（2）KO小鼠表现出完整的即时厌食反应，进食潜伏期增加且进餐量减少。但是，CRF（2）删除取消了约束诱导的厌食症的延长期。 CRF（2）KO小鼠在对食物匮乏或注射生长素释放肽受体激动剂的反应方面与野生型对照没有区别。与基因型无关，食物匮乏会增加食物摄入量，并且进餐量，进餐频率，水：食物比例和进食率会发生显着变化。酰基ghrelin或有效的ghrelin类似物BIM-28131通过增加进餐量（ghrelin，BIM-28131）和进餐量（BIM-28131），同时减慢平均进食速度（BIM-28131），剂量依赖性地刺激食物摄入在WT和KO小鼠中类似。这些结果表明，CRF（2）受体参与进食的积极阶段和急性暴露后的进餐量控制。

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