...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Antagonism of group III metabotropic glutamate receptors results in impairment of LTD but not LTP in the hippocampal CA1 region, and prevents long-term spatial memory.
【24h】

Antagonism of group III metabotropic glutamate receptors results in impairment of LTD but not LTP in the hippocampal CA1 region, and prevents long-term spatial memory.

机译：III类代谢型谷氨酸受体的拮抗作用会导致海马CA1区LTD受损而不是LTP受损，并阻止长期空间记忆。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recently it has emerged that hippocampal long-term depression (LTD) may play an important role in the acquisition and storage of spatial memories. This form of synaptic plasticity is tightly regulated by metabotropic glutamate receptors (mGluRs) that negatively couple to adenylyl cyclase. Activation of group III mGluRs is necessary for persistent hippocampal LTD, but is not required for depotentiation or long-term potentiation (LTP) in the dentate gyrus in vivo. In the CA1 region antagonism of group III mGluRs prevents LTD in vivo. Effects on LTP in vivo are as yet unknown. We investigated the effects of group III mGluR antagonism on LTP and LTD at Schaffer collateral-CA1 synapses, and on spatial learning in the eight-arm radial maze. Daily application of the group III mGluR antagonist (R,S)-alpha-cyclopropyl-4-phosphonophenylglycine (CPPG) resulted in impairment of long-term (reference) memory, with effects becoming apparent 4 days after training and drug treatment began. Short-term (working) memory was unaffected throughout the 10-day study. Application of CPPG prevented LTD, but not LTP, in the CA1 region. These data suggest that activation of group III mGluRs is required for the establishment of spatial long-term memory. Their exclusive role in mediating hippocampal LTD provides correlational evidence for a role for LTD in the type of spatial learning studied.
机译：最近发现海马长期抑郁症（LTD）可能在空间记忆的获取和存储中起重要作用。这种形式的突触可塑性受到与腺苷酸环化酶负偶联的代谢型谷氨酸受体（mGluRs）的严格调控。 III型mGluRs的激活对于持续性海马LTD是必需的，但对于齿状回体内的去势或长期增强（LTP）则不是必需的。在CA1区域，III族mGluRs的拮抗作用在体内阻止了LTD。体内对LTP的影响尚不清楚。我们调查了第三组mGluR拮抗作用在沙弗侧支CA1突触对LTP和LTD的影响，以及对八臂arm骨迷宫中空间学习的影响。每天使用III组mGluR拮抗剂（R，S）-α-环丙基-4-膦酰基苯基甘氨酸（CPPG）会损害长期（参考）记忆，在训练和药物治疗开始后4天这种作用变得明显。在整个10天的研究中，短期（工作）记忆不受影响。 CPPG的应用阻止了CA1地区的LTD，但阻止了LTP。这些数据表明，激活III类mGluRs是建立空间长期记忆所必需的。它们在介导海马LTD中的独特作用为LTD在所研究的空间学习类型中的作用提供了相关的证据。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号