• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Premovement activities in the subthalamic area of patients with Parkinson's disease and their dependence on task.
【24h】

Premovement activities in the subthalamic area of patients with Parkinson's disease and their dependence on task.

机译：帕金森氏病患者的丘脑下区域的运动活动及其对任务的依赖性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Movement preparation and execution are associated with a reduction in oscillatory synchrony over 6-35 Hz (event-related desynchronization; ERD) and increases in oscillatory synchrony at higher frequencies (event-related synchronization; ERS) in the human parkinsonian subthalamic nucleus (STN). The timing of the ERD < 35 Hz in STN correlates with, but precedes, the timing of voluntary movement, in line with a role in motor processing. Here, we explore how directly the synchrony manifest in local field potential (LFP) activities depends on the details of motor processing. To this end, we recorded local field potentials from the STN area of parkinsonian subjects while they performed internally paced single movements or double movements with one hand. Analysis was limited to time periods that were unequivocally premovement, so as to avoid the confounding effects of sensory afferance during movement. LFP power differed from baseline activity as early as 2.1-1.1 s prior to movement over 6-18 Hz and 56-70 Hz.However, only the early changes in LFP power in the 56-70 Hz band depended on task type. Later on, within 0.5 s of the forthcoming movement, the behaviour of both the 6-18 and 56-70 Hz bands differed according to movement type. In addition, a change was seen in LFP activity over 23-35 Hz, although the ERD in this band remained similar across movement types. The findings further implicate the human STN in the feedforward organization of movement in premotor circuits. Different aspects of this organization may be preferentially reflected in changes in synchrony at different frequencies.
机译：运动的准备和执行与6-35 Hz以上的振动同步性降低（事件相关的失步; ERD）以及人帕金森丘脑下丘脑核（STN）中较高频率下的振动同步性（事件相关的同步; ERS）相关。 STN中ERD <35 Hz的时机与自愿运动的时机相关，但要早于其，这与运动过程中的作用一致。在这里，我们探讨了局部场电势（LFP）活动中的同步信号如何直接取决于电机处理的细节。为此，我们记录了帕金森病受试者STN区域的局部场电势，而他们用一只手进行了内部起搏的单步运动或双步运动。分析仅限于明确移动的时间段，以避免运动过程中感觉传入的混淆效应。 LFP功率在移动至6-18 Hz和56-70 Hz之前的2.1-1.1 s之前就不同于基线活动，但是，只有56-70 Hz频段内LFP功率的早期变化取决于任务类型。随后，在即将发生的运动的0.5 s内，6-18和56-70 Hz频带的行为根据运动类型而有所不同。此外，尽管该频段的ERD在所有运动类型中均保持相似，但LFP活性在23-35 Hz范围内有所变化。这些发现进一步暗示了人类STN参与了前电动机回路中运动的前馈组织。该组织的不同方面可能会优先反映在不同频率的同步变化中。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号