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首页> 外文期刊>The European Journal of Neuroscience >The innervation of parvalbumin-containing interneurons by VIP-immunopositive interneurons in the primary somatosensory cortex of the adult rat.
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The innervation of parvalbumin-containing interneurons by VIP-immunopositive interneurons in the primary somatosensory cortex of the adult rat.

机译：VIP免疫阳性中枢神经在成年大鼠的初级体感皮层中对含小白蛋白的中枢神经的神经支配。

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摘要

gamma-Aminobutyric acid (GABA)ergic interneurons of neocortex consist of many subgroups with extremely heterogeneous morphological, physiological and molecular properties. To explore the putative effect of the vasoactive intestinal polypeptide-immunopositive (VIP +) neurons on neocortical circuitry, the number and distribution of VIP + boutons were analysed on somatodendritic domains of 272 parvalbumin immunopositive (PV +) 3D-reconstructed neurons. The synaptic nature of 91% of somatic and 76% of dendritic contacts was verified by electron microscopy. The target PV + neurons were separated in two significantly different groups by means of cluster analysis. The first group (Cluster 1, 26%) received on average five times more VIP + synapses than those of the second group. The second group (Cluster 2, 74%) contained cells that were poorly innervated by VIP + boutons or did not have either somatic or dendritic or any VIP innervation at all. The cells of Cluster 1 had a soma size and total dendritic lengthsignificantly smaller than that of Cluster 2, however, they received three times more dendritic synapses, which resulted in a five times higher VIP + synaptic density on dendrites. Our results showed that although most of the PV + cells are innervated by VIP + boutons at a varying degree, some 6% of PV + cells received no input from VIP + interneurons. This suggests a refined morphological basis to influence the majority of the PV + interneurons, which are very effectively controlling pyramidal cell firing. Together with metabolic and neuromodulatory effects of VIP, this would probably result in an enhanced responsiveness of the latter cell type to tactile stimuli.
机译：大脑皮层的γ-氨基丁酸（GABA）能中神经元由许多亚组组成，这些亚组的形态，生理和分子特性极为不同。为了探讨血管活性肠多肽免疫阳性（VIP +）神经元对新皮层回路的假定作用，分析了272个小白蛋白免疫阳性（PV +）3D重建神经元的树突状结构域中VIP + bouton的数量和分布。电子显微镜证实了91％的体细胞接触和76％的树突接触的突触性质。通过聚类分析，将目标PV +神经元分为两个明显不同的组。第一组（组1，26％）平均收到的VIP +突触比第二组多五倍。第二组（第2组，占74％）包含的细胞受VIP +布顿神经支配的能力较弱，或者根本没有体细胞或树突状细胞或任何VIP的支配能力。簇1的细胞的体细胞大小和总树突长度显着小于簇2的细胞，但是，它们接受的树突突突的三倍多，这导致树突上的VIP +突触密度高了五倍。我们的结果表明，尽管大多数PV +细胞受VIP +布顿神经支配的程度不同，但仍有大约6％的PV +细胞没有受到VIP +中子的输入。这暗示了精炼的形态学基础可影响大多数PV +中间神经元，它们非常有效地控制了锥体细胞的发射。连同VIP的代谢和神经调节作用，这可能会导致后者细胞类型对触觉刺激的反应性增强。

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