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首页> 外文期刊>The European Journal of Neuroscience >Inactivation of the prelimbic, but not infralimbic, prefrontal cortex impairs the contextual control of response conflict in rats.
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Inactivation of the prelimbic, but not infralimbic, prefrontal cortex impairs the contextual control of response conflict in rats.

机译：前肢前额叶皮层的失活，但不是下肢前额叶皮层的失活，损害了大鼠反应冲突的情境控制。

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One fundamental function of the prefrontal cortex (PFC) is to guide context-appropriate behaviour in situations of response conflict. Haddon and Killcross recently developed a task in rats which mimics some aspects of response conflict seen in human cognitive paradigms such as the Stroop task. Using this paradigm they demonstrated that large PFC lesions including the prelimbic (PL), infralimbic (IL) and anterior cingulate cortices (ACC) selectively impaired performance on incongruent trials which required the use of task-setting contextual cues to control responding in the face of ambiguous response information. The current experiment was conducted to determine whether specific PFC regions were responsible for the deficit in incongruent performance. Rats were trained on two instrumental biconditional discriminations, one auditory and one visual, in two different contexts. Following acquisition, rats were implanted with guide cannulae aimed at the PL or the IL cortices of the rat prefrontal cortex. Following retraining, rats received microinfusions of the GABA(A) agonist muscimol or artificial cerebrospinal fluid (aCSF) into either the PL or the IL prior to presentations of novel congruent and incongruent audiovisual compounds of the training stimuli in extinction. Results showed that temporary inactivation of the PL cortex led to a selective deficit on incongruent compound trials, but left congruent, and hence biconditional task performance intact. By contrast, IL inactivation had no effect on the accuracy of responding during either congruent or incongruent trials. These results suggest that the PL cortex is necessary for the use of task-setting contextual cues to control responding to conflicting information.
机译：前额叶皮层（PFC）的一项基本功能是在响应冲突的情况下指导适合情境的行为。 Haddon和Killcross最近在大鼠中开发了一项任务，该任务模仿了人类认知范例（例如Stroop任务）中出现的反应冲突的某些方面。他们使用这种范例证明，在不相符的临床试验中，包括前肢（PL），下肢（IL）和前扣带回皮质（ACC）在内的较大的PFC病变选择性地损害了患者的表现，这就需要使用任务设定的上下文线索来控制面对患者的反应响应信息不明确。进行了当前实验，以确定特定的PFC区域是否造成不一致的性能不足。在两种不同的情况下，对大鼠进行了两种工具性双条件辨别训练，一种是听觉上的，另一种是视觉上的。采集后，向大鼠植入针对大鼠前额叶皮层的PL或IL皮质的引导套管。再训练后，大鼠接受了GABA（A）激动剂麝香酚或人工脑脊髓液（aCSF）的微滴注，注入了PL或IL中，然后出现了新的一致和不一致的训练刺激音像化合物，从而灭绝了。结果表明，PL皮质的暂时失活导致不一致的复合试验中的选择性缺陷，但保持一致，因此双条件任务执行完好无损。相比之下，IL灭活对全同或非全同试验的反应准确性没有影响。这些结果表明，PL皮质对于使用任务设置上下文提示来控制对冲突信息的响应是必要的。

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