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首页> 外文期刊>The European Journal of Neuroscience >Synaptic organization and input-specific short-term plasticity in anterior cingulate cortical neurons with intact thalamic inputs.
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Synaptic organization and input-specific short-term plasticity in anterior cingulate cortical neurons with intact thalamic inputs.

机译：丘脑输入完整的前扣带回皮质神经元中的突触组织和特定于输入的短期可塑性。

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摘要

The absence of a slice preparation with intact thalamocortical pathways has held back elucidation of the cellular and synaptic mechanisms by which thalamic signals are differentially transmitted to and processed in the anterior cingulate cortex (ACC). In this report we introduce an innovative mouse brain slice preparation in which it is possible to explore the electrophysiological properties of ACC neurons with intact long-distance inputs from medial thalamic (MT) nuclei by intracellular recordings; this MT-ACC neuronal pathway plays an integral role in information transmission. Biocytin-labeled fibers in a functional slice could be traced anterogradely or retrogradely from the MT via the reticular thalamic nuclei, striatum and corpus callosum to the cingulate cortical areas. Eighty-seven cells downstream of the thalamic projections in 49 slices were recorded intracellularly. Intracellular recordings in the ACC showed that thalamocingulate transmission involves both alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate and N-methyl-D-aspartate (NMDA) subtypes of glutamate receptors. Thalamus-evoked responses recorded extracellularly in the ACC were activated and progressed along a deep-superficial-deep trajectory loop across the ACC layers. We observed enhanced paired-pulse facilitation and tetanic potentiation of thalamocingulate synapses, suggestive of input-specific ACC plasticity and selective processing of information relayed by thalamocingulate pathways. Furthermore, we observed differential responses of ACC neurons to thalamic burst stimulation, which underscores the importance of MT afferents in relaying sensory information to the ACC. This new slice preparation enables the contribution of MT-evoked ACC synaptic transmission to short-term plasticity in the neuronal circuitry underlying sensory information processing to be examined in detail.
机译：缺乏具有完整的丘脑皮质通路的切片制剂的研究阻碍了对细胞和突触机制的阐明，通过该机制，丘脑信号被差异地传递至前扣带回皮层（ACC）并在前扣带回皮层（ACC）中进行处理。在本报告中，我们介绍了一种创新的小鼠脑切片制剂，通过细胞内记录，可以探索来自内侧丘脑（MT）核完整长途输入的ACC神经元的电生理特性;这种MT-ACC神经元途径在信息传递中起着不可或缺的作用。功能切片中生物素标记的纤维可以从MT经由网状丘脑核，纹状体和call体顺行或逆行追踪到扣带回皮层区域。在细胞内记录了49个切片中丘脑突起下游的87个细胞。 ACC中的细胞内记录显示，丘脑丁草酸酯的传递涉及谷氨酸受体的亚型，包括α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）/海藻酸酯和N-甲基-D-天冬氨酸（NMDA）亚型。 ACC胞外记录的丘脑诱发反应被激活，并沿着ACC层的深层-深层-深层轨迹循环进行。我们观察到丘脑突触突触的成对脉冲促进和强直性增强，提示输入特定的ACC可塑性和通过丘脑突触途径传递的信息的选择性处理。此外，我们观察到ACC神经元对丘脑爆发刺激的不同反应，这突显了MT传入将感觉信息传递给ACC的重要性。这种新的切片准备使MT诱发的ACC突触传递对感觉信息处理基础的神经元电路中短期可塑性的贡献得以详细检查。

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