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首页> 外文期刊>The European Journal of Neuroscience >Empirical tests of the functional significance of amygdala-based modulation of hippocampal representations: evidence for multiple memory consolidation pathways.
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Empirical tests of the functional significance of amygdala-based modulation of hippocampal representations: evidence for multiple memory consolidation pathways.

机译：基于杏仁核的海马表征调节功能意义的实证检验：多种记忆整合途径的证据。

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This series of experiments evaluated the effects of amygdala damage on the acquisition and long-term retention of variants of the water task, and tested the hypothesis that the amygdala is an essential neural system for consolidation of hippocampal memories. In Experiment 1, rats with large, neurotoxic lesions of the amygdala (AMYG) showed normal acquisition on the standard spatial version of the water task, as well as normal retention and decay rate profiles on the 24-h and 30-day retention probes. In Experiment 2, AMYG rats showed normal one-trial place learning abilities and could retain this one-trial information over a 24 h delay. Experiment 3 showed that the amygdala lesions used in this study were functionally significant because AMYG rats, from Experiment 2, showed impairments in a discriminative fear conditioning to context paradigm. Experiment 4 was a critical test of the idea that the amygdala is a decisive locus for consolidation of hippocampal memories. AMYG rats were trained to sub-asymptotic levels of performance on the standard version of the water task. Following each training session, the subjects were given a post-training peripheral injection of D-amphetamine. A probe test revealed that normal subjects and AMYG rats showed similar post-training memory improvement effects. Taken together, the results show that hippocampal memory consolidation processes do not require amygdala modulation. Arguments for an alternative view are presented suggesting that there are multiple memory consolidation pathways, one of which may depend on amygdala neural circuitry.
机译：这一系列实验评估了杏仁核损伤对水任务变体的获取和长期保留的影响，并验证了杏仁核是巩固海马记忆必不可少的神经系统的假设。在实验1中，具有杏仁核较大神经毒性病变（AMYG）的大鼠在水任务的标准空间版本上显示正常采集，在24小时和30天保留探针上显示出正常保留和衰变速率曲线。在实验2中，AMYG大鼠表现出正常的一审位置学习能力，并且可以在24小时的延迟后保留该一审信息。实验3表明，在这项研究中使用的杏仁核病变在功能上很重要，因为实验2的AMYG大鼠在针对情景范式的歧视性恐惧条件下表现出损伤。实验4是对杏仁核是巩固海马记忆的决定性基因座这一观点的关键测试。在水任务的标准版本上，对AMYG大鼠进行训练，使其达到亚渐近水平的表现。在每次训练之后，对受试者进行D-苯异丙胺的训练后外周注射。探针测试显示正常受试者和AMYG大鼠显示出类似的训练后记忆改善效果。两者合计，结果表明海马记忆巩固过程不需要杏仁核调制。提出了另一种观点的观点，表明存在多种记忆整合途径，其中一种可能取决于杏仁核神经回路。

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