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首页> 外文期刊>The European Journal of Neuroscience >Reversible inactivation of amygdala and cerebellum but not perirhinal cortex impairs reactivated fear memories.
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Reversible inactivation of amygdala and cerebellum but not perirhinal cortex impairs reactivated fear memories.

机译：杏仁核和小脑的可逆失活，而不是周围神经皮层的失活损害了重新激活的恐惧记忆。

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The cerebellum, amygdala and perirhinal cortex are involved in fear learning but the different roles that these three structures play in aversive learning are not well defined. Here we show that in adult rats amygdala or cerebellar vermis blockade causes amnesia when performed immediately, but not 1 h, after the recall of fear memories. Thus, the cerebellum, as well as the amygdala, influences long-term fear memories. These effects are long lasting, as they do not recover over time, even after a reminder shock administration. However, all of the subjects were able to form new fear memories in the absence of inactivation. By increasing the strength of conditioning, we observed that stronger fear memories are affected by the combined but not independent amygdala and cerebellar blockade. These results demonstrate that the cerebellum supports the memory processes even in the absence of a crucial site for emotions like the amygdala. Furthermore, they suggest that the amygdala is only one of the neural sitesunderlying long-term fear memories. Finally, the inactivation of the perirhinal cortex never alters retrieved fear traces, showing important differences between the amygdala, cerebellum and perirhinal cortex in emotional memories.
机译：小脑，杏仁核和周围神经皮层参与恐惧学习，但是这三种结构在厌恶学习中所起的不同作用尚不明确。在这里，我们显示在成年大鼠中，杏仁核或小脑ver部阻滞在回忆恐惧记忆后立即（而非1小时）执行时会引起健忘症。因此，小脑以及杏仁核都会影响长期恐惧记忆。这些效果是持久的，因为即使经过提醒电击治疗，它们也不会随着时间恢复。然而，在没有灭活的情况下，所有受试者都能形成新的恐惧记忆。通过增加调节的强度，我们观察到较强的恐惧记忆受杏仁核和小脑阻滞合并但非独立的影响。这些结果表明，即使没有像杏仁核这样的重要情绪部位，小脑也支持记忆过程。此外，他们认为杏仁核只是长期恐惧记忆背后的神经部位之一。最后，灭活周围神经皮层永远不会改变检索到的恐惧痕迹，显示杏仁核，小脑和周围神经皮层之间在情感记忆上有重要区别。

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