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首页> 外文期刊>The European Journal of Neuroscience >Tactile responses of hindpaw, forepaw and whisker neurons in the thalamic ventrobasal complex of anesthetized rats.
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Tactile responses of hindpaw, forepaw and whisker neurons in the thalamic ventrobasal complex of anesthetized rats.

机译：麻醉大鼠丘脑腹基底复合物中后足，前爪和晶须神经元的触觉反应。

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The majority of studies investigating responses of thalamocortical neurons to tactile stimuli have focused on the whisker representation of the rat thalamus: the ventral-posterior-medial nucleus (VPM). To test whether the basic properties of thalamocortical responses to tactile stimuli could be extended to the entire ventrobasal complex, we recorded single neurons from the whisker, forepaw and hindpaw thalamic representations. We performed a systematic analysis of responses to stereotyped tactile stimuli--500 ms pulses (i.e. ON-OFF stimuli) or 1 ms pulses (i.e. impulsive stimuli)--under two different anesthetics (pentobarbital or urethane). We obtained the following main results: (i) the tuning of cells to ON vs. OFF stimuli displayed a gradient across neurons, so that two-thirds of cells responded more to ON stimuli and one-third responded more to OFF stimuli; (ii) on average, response magnitudes did not differ between ON and OFF stimuli, whereas latencies of response to OFF stimuli were a few milliseconds longer; (iii) latencies of response to ON and OFF stimuli were highly correlated; (iv) responses to impulsive stimuli and ON stimuli showed a strong correlation, whereas the relationship between the responses to impulsive stimuli and OFF stimuli was subtler; (v) unlike ON responses, OFF responses did not decrease when stimuli were moved from the receptive field center to a close location in the excitatory surround. We obtained the same results for hindpaw, forepaw and whisker neurons. Our results support the view of a neurophysiologically homogeneous ventrobasal complex, in which OFF responses participate in the structure of the spatiotemporal receptive field of thalamocortical neurons for tactile stimuli.
机译：大多数研究丘脑皮质神经元对触觉刺激的反应的研究都集中在大鼠丘脑的晶须表示上：腹后后内侧核（VPM）。为了测试丘脑皮质对触觉刺激的反应的基本特性是否可以扩展到整个腹基复合体，我们记录了晶须，前爪和后爪丘脑表征中的单个神经元。我们对两种定型麻醉剂（五苯甲酸酯或尿烷）下对定型触觉刺激（500 ms脉冲（即ON-OFF刺激）或1 ms脉冲（即冲动刺激））的响应进行了系统分析。我们获得了以下主要结果：（i）将细胞调整为ON和OFF刺激在整个神经元上显示出梯度，因此三分之二的细胞对ON刺激的反应更多，三分之一对OFF刺激的反应更多; （ii）平均而言，ON和OFF刺激之间的反应幅度没有差异，而对OFF刺激的反应延迟时间则延长了几毫秒; （iii）对ON和OFF刺激的反应潜伏期高度相关; （iv）对冲动刺激和ON刺激的反应显示出很强的相关性，而对冲动刺激和OFF刺激的反应之间的关系微妙。 （v）与ON响应不同，当将刺激从感受野中心转移到兴奋性周围的闭合位置时，OFF响应不会减少。对于后爪，前爪和晶须神经元，我们获得了相同的结果。我们的结果支持一种神经生理学上统一的腹基复合体的观点，其中OFF反应参与了丘脑皮质神经元对触觉刺激的时空感受野的结构。

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