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首页> 外文期刊>The European physical journal, E. Soft matter >Spontaneous condensation in DNA-polystyrene-b-poly(l-lysine) polyelectrolyte block copolymer mixtures
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Spontaneous condensation in DNA-polystyrene-b-poly(l-lysine) polyelectrolyte block copolymer mixtures

机译：DNA-聚苯乙烯-b-聚（1-赖氨酸）聚电解质嵌段共聚物混合物中的自发缩合

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摘要

We investigated the condensation of calf thymus DNA by amphiphilic polystyrene(m)-b-poly(l-lysine)(n) block copolymers (PSm-b- PLys(n), m, n = degree of polymerization), using small-angle X-ray scattering, polarized optical microscopy and laser scanning confocal microscopy. Microscopy studies showed that the DNA condenses in the form of fibrillar precipitates, with an irregular structure, due to electrostatic interactions between PLys and DNA. This is not modified by the presence of hydrophobic PS block. Scattering experiments show that the structure of the polyplexes corresponds to a local order of DNA rods which becomes more compact upon increasing n. It can be concluded that for DNA/ PSm-b- PLys(n) polyplexes, the balance between the PLys block length and the excess charge in the system plays an essential role in the formation of a liquid crystalline phase.
机译：我们研究了两亲性聚苯乙烯（m）-b-聚（l-赖氨酸）（n）嵌段共聚物（PSm-b-PLys（n），m，n =聚合度）与小牛胸腺DNA的缩合反应，角X射线散射，偏振光学显微镜和激光扫描共聚焦显微镜。显微镜研究表明，由于PLys与DNA之间的静电相互作用，DNA以原纤维状沉淀的形式凝结，具有不规则的结构。疏水性PS嵌段的存在并不能改变这一点。散射实验表明，多链体的结构对应于DNA棒的局部顺序，该顺序随着n的增加而变得更加紧密。可以得出结论，对于DNA / PSm-b-PLys（n）多聚物，PLys嵌段长度与系统中过量电荷之间的平衡在液晶相的形成中起着至关重要的作用。

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