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首页> 外文期刊>The East African medical journal >Haematological alterations in leprosy patients treated with dapsone.
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Haematological alterations in leprosy patients treated with dapsone.

机译：氨苯砜治疗的麻风病患者的血液学改变。

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摘要

OBJECTIVE: To evaluate the haemoglobin concentration (Hb); total white blood cell count (WBC), differential WBC count; platelet count and reticulocyte count in leprosy patients already treated with dapsone. DESIGN: A case-control study. SETTING: Specialist Hospital Ossiomo, which is a Leprosarium and Haematology laboratory, University of Benin Teaching Hospital (UBTH), Nigeria. SUBJECTS: Seventy six leprosy patients (forty males and thirty six females) age range 13-40 years on single dose dapsone. RESULTS: The haemoglobin concentration showed a marked decrease while the reticulocyte count was markedly elevated which was suggestive of haemolytic anaemia. There was also lymphocytosis in patients during pre and post dapsone therapy. CONCLUSION: Leprosy patients on a dosage of 100 mg dapsone, are prone to haemolytic anaemia. Leprosy patients should routinely have their Hb, WBC, platelet count and reticulocyte count determined, while on dapsone therapy in order to ascertain the presence of haemolysis.
机译：目的：评估血红蛋白浓度（Hb）。总白细胞计数（WBC），差异白细胞计数;已经使用氨苯砜治疗的麻风病患者的血小板计数和网织红细胞计数。设计：病例对照研究。地点：奥西莫专科医院，是尼日利亚贝宁大学教学医院（UBTH）的麻风病和血液学实验室。受试者：76例麻风患者（男性40例，女性36例），单剂量氨苯砜的年龄范围为13-40岁。结果：血红蛋白浓度明显降低，而网织红细胞计数明显升高，提示溶血性贫血。氨苯砜治疗前后患者也有淋巴细胞增多。结论：麻风患者服用氨苯砜100 mg易发生溶血性贫血。麻风患者在进行氨苯砜治疗时应常规确定其血红蛋白，白细胞，血小板计数和网织红细胞计数，以确定溶血的存在。

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