The importance of being dimeric

Mei G; Di Venere A; Rosato N; Finazzi-Agro A

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The importance of being dimeric

机译：二聚体的重要性

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Why are there so many dimeric proteins and enzymes? While for heterodimers a functional explanation seems quite reasonable, the case of homodimers is more puzzling. The number of homodimers found in all living organisms is rapidly increasing. A thorough inspection of the structural data from the available literature and stability (measured from denaturation-renaturation experiments) allows one to suggest that homodimers can be divided into three main types according to their mass and the presence of a (relatively) stable monomeric intermediate in the folding-unfolding pathway. Among other explanations, we propose that an essential advantage for a protein being dimeric, may be the proper and rapid assembly in the cellular milieu.

机译：为什么会有这么多的二聚体蛋白质和酶？对于异二聚体，功能上的解释似乎是很合理的，但同二聚体的情况更令人费解。在所有活生物体中发现的同二聚体的数量正在迅速增加。对现有文献中的结构数据和稳定性（通过变性-变性实验测量）进行的全面检查，使人们认为，同二聚体可根据其质量和（相对）稳定的单体中间体的存在而分为三种主要类型。折叠-展开路径。除其他解释外，我们提出蛋白质为二聚体的基本优点可能是在细胞环境中正确而快速地组装。

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《The FEBS journal》 |2005年第1期|共12页
作者
Mei G; Di Venere A; Rosato N; Finazzi-Agro A;
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正文语种 eng
中图分类生物化学;
关键词
MONOMERIC INTERMEDIATE; CONFORMATIONAL STABILITY; ESCHERICHIA-COLI; THERMODYNAMIC CHARACTERIZATION; EQUILIBRIUM DENATURATION; REVERSIBLE DISSOCIATION; QUANTITATIVE-ANALYSIS; ACCESSIBLE SURFACE; ACID-PHOSPHATASE; CONTACT ORDER;

机译：单分子中间体;构象稳定性;大肠埃希氏菌;热力学表征;平衡去饱和度;可逆离解;定量分析;可接触表面;酸磷酸;接触顺序;

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The importance of being dimeric

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