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Cancer stem cells - important players in tumor therapy resistance

机译:癌症干细胞-抗肿瘤治疗的重要角色

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摘要

Resistance to tumor therapy is an unsolved problem in cancer treatment. A plethora of studies have attempted to explain this phenomenon and many mechanisms of resistance have been suggested over recent decades. The concept of cancer stem cells (CSCs), which describes tumors as hierarchically organized, has added a new level of complexity to therapy failure. CSCs are the root of cancers and resist chemo- and radiotherapy, explaining cancer recurrence even many years after therapy is ended. This review discusses briefly CSCs in cancers, gives an overview of the role of CSCs in therapy resistance, and discusses the potential means of targeting these therapy-resistant tumor cells.
机译:对肿瘤治疗的抗性是癌症治疗中尚未解决的问题。大量的研究试图解释这种现象,并且在最近的几十年中已经提出了许多抵抗机制。癌症干细胞(CSCs)的概念将肿瘤按层次组织,将治疗失败的复杂性提高到了一个新的水平。 CSC是癌症的根源,可以抵抗化学疗法和放射疗法,从而解释了即使在治疗结束多年后仍会复发的癌症。这篇综述简要讨论了癌症中的CSCs,概述了CSCs在治疗耐药性中的作用,并讨论了靶向这些治疗耐药性肿瘤细胞的潜在手段。

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