The power of integrating kinetic isotope effects into theformalism of the Michaelis-Menten equation

Judith P. Klinman

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The power of integrating kinetic isotope effects into theformalism of the Michaelis-Menten equation

机译：将动力学同位素效应整合到Michaelis-Menten方程的形式主义中的能力

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The final arbiter of enzyme mechanism is the ability to establish and test akinetic mechanism. Isotope effects play a major role in expanding the scopeand insight derived from the Michaelis-Menten equation. The integrationof isotope effects into the formalism of the Michaelis-Menten equationbegan in the 1970s and has continued until the present. This review discussesa family of eukaryotic copper proteins, including dopamine beta-monooxygenase,tyramine beta-monooxygenase and peptidylglycine alpha-amidatingenzyme, which are responsible for the synthesis of neuroactive compounds,norepinephrine, octopamine and C-terminally carboxamidated peptides,respectively. The review highlights the results of studies showing how combiningkinetic isotope effects with initial rate parameters permits the evaluation

机译：酶机制的最终仲裁者是建立和测试运动机制的能力。同位素效应在扩大从Michaelis-Menten方程得出的范围和见解方面起着重要作用。 1970年代开始将同位素效应整合到Michaelis-Menten方程的形式主义中，一直持续到现在。这篇综述讨论了一个真核铜蛋白家族，包括多巴胺β-单加氧酶，酪胺β-单加氧酶和肽基甘氨酸α-酰胺化酶，它们分别负责神经活性化合物，去甲肾上腺素，章鱼胺和C末端羧酰胺化肽的合成。该评论着重介绍了研究结果，这些研究表明将动力学同位素效应与初始速率参数结合起来可以进行评估

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《The FEBS journal》 |2014年第2期|共9页
作者
Judith P. Klinman;
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正文语种 eng
中图分类生物化学;
关键词
enzymatic C-H activation; kinetic isotopeeffects; mechanism of enzyme action; mechanism of two coppermonooxygenases; steady-state kinetics;

机译：酶促C-H活化;动力学同位素效应;酶作用机理;两种铜单加氧酶的机理;稳态动力学;

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1. The power of integrating kinetic isotope effects into theformalism of the Michaelis-Menten equation [J] . Judith P. Klinman The FEBS journal . 2014,第2期

机译：将动力学同位素效应整合到Michaelis-Menten方程的形式主义中的能力
2. HO + CO reaction rates and H/D kinetic isotope effects: Master equation models with ab initio SCTST rate constants [J] . Weston R.E., Nguyen T.L., Stanton J.F., The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory . 2013,第5期

机译：HO + CO反应速率和H / D动力学同位素效应：具有从头算起SCTST速率常数的主方程模型
3. Optimal methods for estimating kinetic isotope effects from different forms of the Rayleigh distillation equation [J] . Scott KM., Lu X., Cavanaugh CM., Geochimica et Cosmochimica Acta: Journal of the Geochemical Society and the Meteoritical Society . 2004,第3期

机译：从瑞利蒸馏方程的不同形式估算动力学同位素效应的最佳方法
4. Effects of Estrogen Contamination on Human Cells: Modeling and Prediction Based on Michaelis-Menten Kinetics [C] . Ibrahim F., Biao Huang, Xing J.Z., Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009 . 2009

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5. Reduced models of networks of coupled enzymatic reactions and linearization of Michaelis-Menten differential equations [D] . Kumar, Ajit 2011

机译：耦合酶反应和Michaelis-Menten微分方程线性化的网络简化模型
6. The Power of Integrating Kinetic Isotope Effects into the Formalism of the Michaelis-Menten Equation [O] . Judith P. Klinman -1

机译：将动力学同位素效应整合到Michaelis-Menten方程式中的能力
7. Transport and kinetics in electrocatalytic thin film conducting polymer biosensors: bounded diffusion with Michaelis-Menten kinetics incorporating general inhibition effects [O] . Michael EG Lyons 2020

机译：电催化薄膜传导聚合物生物传感器的运输和动力学：掺入一般抑制作用的偏心扩散

The power of integrating kinetic isotope effects into theformalism of the Michaelis-Menten equation

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