Histatins: salivary peptides with copper(II)- andzinc(II)-binding motifsPerspectives for biomedical applications

Sonia Melino; Celeste Santone; Paolo Di Nardo; Bibudhendra Sarkar

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Histatins: salivary peptides with copper(II)- andzinc(II)-binding motifsPerspectives for biomedical applications

机译：Histatins：具有铜（II）和锌（II）结合基序的唾液肽生物医学应用前景

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Natural antimicrobial peptides represent a primordial mechanism of immunityin both vertebrate and nonvertebrate organisms. Among them, histatinsbelong to a family of human salivary metal-binding peptidesdisplaying potent antibacterial, antifungal and wound-healing activities.These properties, along with the ability of histatins to inhibit collagenasesand cysteine proteases, have attracted much attention for their potentialuse in the treatment of several oral diseases. This review critically assessesthe studies carried out to date in order to provide a comprehensive andsystematic vision of the information accumulated so far. In particular, therelationship between metal-binding and peptide activity is extensively analysed.The review provides important clues for developing possible therapeuticapplications of histatins and their synthetic peptide analogues bycreating a set of necessary resource materials to support investigators andindustries interested in exploiting their unique properties.

机译：天然抗菌肽代表了脊椎动物和非脊椎动物生物体中免疫力的主要机制。其中，组蛋白属于人类唾液金属结合肽家族，具有强大的抗菌，抗真菌和伤口愈合活性，这些特性以及组蛋白抑制胶原酶和半胱氨酸蛋白酶的能力，因其在治疗糖尿病中的潜在用途而备受关注。几种口腔疾病。这篇综述严格地评估了迄今为止进行的研究，以便对迄今为止积累的信息提供全面而系统的看法。特别是，广泛分析了金属结合和肽活性之间的关系。该综述通过创建一组必要的资源材料来支持对研究其独特特性感兴趣的研究人员和行业，为开发组蛋白及其合成肽类似物的可能的治疗应用提供了重要线索。

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《The FEBS journal》 |2014年第3期|共16页
作者
Sonia Melino; Celeste Santone; Paolo Di Nardo; Bibudhendra Sarkar;
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正文语种 eng
中图分类生物化学;
关键词
ACTUN motif; antimicrobial peptides; Candida albicans; histidine rich peptide; metallopeptides; metalloprotease inhibitor; reactive oxygen species; saliva; woundhealing;

机译：ACTUN基序;抗菌肽;白色念珠菌;富含组氨酸的肽;金属肽;金属蛋白酶抑制剂;活性氧;唾液;伤口愈合;

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1. Histatins: salivary peptides with copper(II)- andzinc(II)-binding motifsPerspectives for biomedical applications [J] . Sonia Melino, Celeste Santone, Paolo Di Nardo, The FEBS journal . 2014,第3期

机译：Histatins：具有铜（II）和锌（II）结合基序的唾液肽生物医学应用前景
2. Copper(II) interaction with unstructured prion domain outside the octarepeat region: Speciation, stability, and binding details of copper(II) complexes with PrP106-126 peptides [J] . Di Natale G, Grasso G, Impellizzeri G, Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2005,第20期

机译：铜（II）与八边形区域外的非结构化pr病毒域的相互作用：铜（II）与PrP106-126肽复合物的形态，稳定性和结合细节
3. Copper(II) complexes of peptide fragments of the prion protein. Conformation changes induced by copper(II) and the binding motif in C-terminal protein region [J] . Brown DR, Guantieri V, Grasso G, Journal of Inorganic Biochemistry: An Interdisciplinary Journal . 2004,第1期

机译：ion病毒蛋白肽片段的铜（II）配合物。铜（II）诱导的构象变化和C端蛋白区域的结合基序
4. Tannin (Procyanidins) Binding to a Salivary Peptide (Histatin 5) studied using Electrospray Ionization Tandem Mass Spectrometry (ESI-MS/MS) and Molecular Simulations [C] . Joshua Shraberg, Steven W. Rick, Nalaka Rannulu, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：用电喷雾电离串联质谱法（ESI-MS / MS）和分子模拟研究了与唾液肽（Histatin 5）结合的单宁（Procyanidins）结合
5. Chemistry of copper peptide complexes: Alkoxide coordination in copper(II) and copper(III) peptide complexes, and base decomposition of copper(III) peptide complexes [D] . Wang, Lihua. 1991

机译：铜肽络合物的化学：铜（II）和铜（III）肽络合物中的醇配位，以及铜（III）肽络合物的碱分解
6. Further characterization of the N-terminal copper(II)- and nickel(II)-binding motif of proteins. Studies of metal binding to chicken serum albumin and the native sequence peptide. [O] . P F Predki, C Harford, P Brar, 1992

机译：蛋白质的N末端铜（II）和镍（II）结合基序的进一步表征。金属结合鸡血清白蛋白和天然序列肽的研究。
7. Histatins: salivary peptides with copper(II)- and zinc(II)-binding motifs Perspectives for biomedical applications. [O] . Melino, S, Santone, C, Di Nardo, P, 2013

机译：Histatins：具有铜（II）和锌（II）结合基序的唾液肽，用于生物医学应用。

Histatins: salivary peptides with copper(II)- andzinc(II)-binding motifsPerspectives for biomedical applications

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