A Convenient Method for the Preparations of Carboxamides and Peptides by Using Di(2-pyridyl) Carbonate and O,O'-Di(2-pyridyl) Thiocarbonate as Dehydrating Reagents

Isamu Shiina; Yoshihito Suenaga; Masakazu Nakano; Teruaki Mukaiyama

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A Convenient Method for the Preparations of Carboxamides and Peptides by Using Di(2-pyridyl) Carbonate and O,O'-Di(2-pyridyl) Thiocarbonate as Dehydrating Reagents

机译：以碳酸二（2-吡啶基）酯和O，O'-二（2-吡啶基）硫代碳酸酯为脱水剂制备羧酰胺和肽的简便方法

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Preparations of carboxamides and peptides ar performed inhigh yields from free arboxylic aids and amines by dehydration condensation using di(2-pyridyl) carbonate (DPC) or O,O'-di(2-pyridyl) thiocarbonate (DPTC) in the presence of a catalytic amount of 4-(dimethylamino)pyridine (DMAP). The formation of 2-pyridyl esters, key intermediates of the reaction, from carboxylic acids by using DPC proceeded faster than by using DPTC; therefore, the former carbonate is more efficiently employed inthe above condensation reactions.

机译：甲酰胺和多肽的制备可以通过游离缩水助剂和胺类在碳酸氢二（2-吡啶基）酯或O，O'-二（2-吡啶基）硫代碳酸酯（DPTC）的作用下进行脱水缩合而获得。催化量的4-（二甲基氨基）吡啶（DMAP）。使用DPC由羧酸形成2-吡啶基酯（反应的关键中间体）的过程比使用DPTC进行得更快。因此，在上述缩合反应中更有效地使用前一种碳酸盐。

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《Bulletin of the Chemical Society of Japan》 |2000年第12期|共8页
作者
Isamu Shiina; Yoshihito Suenaga; Masakazu Nakano; Teruaki Mukaiyama;
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正文语种 eng
中图分类化学;化学工业;
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1. A Convenient Method for the Preparations of Carboxamides and Peptides by Using Di(2-pyridyl) Carbonate and O,O'-Di(2-pyridyl) Thiocarbonate as Dehydrating Reagents [J] . Isamu Shiina, Yoshihito Suenaga, Masakazu Nakano, Bulletin of the Chemical Society of Japan . 2000,第12期

机译：以碳酸二（2-吡啶基）酯和O，O'-二（2-吡啶基）硫代碳酸酯为脱水剂制备羧酰胺和肽的简便方法
2. O,O '-Di(2-pyridyl) thiocarbonate as an efficient reagent for the preparation of carboxylic esters from highly hindered alcohols [J] . Saitoh K., Mukaiyama T., Shiina I. Chemistry Letters . 1998,第7期

机译：O，O'-二（2-吡啶基）硫代碳酸酯作为从高位阻醇制备羧酸酯的有效试剂
3. Convenient Method for the Preparation of Active Carbonates, Active Carbamates, and Ureas Using Di-2-Pyridyl Carbonate [J] . Suggak Kim, Young Kwan Ko Bulletin of the Korean Chemical Society . 1985,第3期

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4. Preparation of Indole-Containing 3-(2-Pyridyl)-1,2,4-Triazines as Tryptamine Derivatives [C] . Maria I. Savchuk, Dmitry S. Kopchuk, Alexey P. Krinochkin, International Conference on Modern Synthetic Methodologies for Creating Drugs and Functional Materials . 2019

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机译：I.叔芳基磺酰胺作为镍催化的Kumada-Corriu-Tamao还原和碳-碳键形成交叉偶联反应的新交叉偶联伴侣。二。在温和的镍（0）下N-磺酰基脱保护催化了Kumada-Corriu-Tamao偶联条件和N-Ans保护基的发展。三， 3,3'-二-（2-吡啶基）-1,1'-bi-2-萘酚配体的合成及应用
6. Di(2-Pyridyl) Carbonate Promoted Alkoxycarbonylation of Amines: A Convenient Synthesis of Functionalized Carbamates [O] . Arun K. Ghosh, Tien T. Duong, Sean P. McKee -1

机译：碳酸二（2-吡啶基）酯促进胺的烷氧羰基化：功能化氨基甲酸酯的简便合成
7. Kinetics and Reaction Mechanism of Aminolyses of Benzyl 2-Pyridyl Carbonate and t-Butyl 2-Pyridyl Carbonate in Acetonitrile [O] . Ae-Ri Bae, Ik-Hwan Um 2012

机译：乙腈中苄基2-吡啶碳酸亚氨基酯和叔丁基2-吡啶基2-吡啶基碳酸酯的动力学和反应机制

A Convenient Method for the Preparations of Carboxamides and Peptides by Using Di(2-pyridyl) Carbonate and O,O'-Di(2-pyridyl) Thiocarbonate as Dehydrating Reagents

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