Branched chain mechanism of polymerization and ultrastructure of prion protein amyloid fibrils

Baskakov IV

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Branched chain mechanism of polymerization and ultrastructure of prion protein amyloid fibrils

机译：ion病毒蛋白淀粉样原纤维聚合和超微结构的支链机理

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The discovery of prion disease and the establishment of the protein only hypothesis of prion propagation raised substantial interest in the class of maladies referred to as conformational diseases. Although significant progress has been made in elucidating the mechanisms of polymerization for several amyloidogenic proteins and peptides linked to conformational disorders and solving their fibrillar 3D structures, studies of prion protein amyloid fibrils and their polymerization mechanism have proven to be very difficult. The present minireview introduces the mechanism of branched-chain reaction for describing the peculiar kinetics of prion polymerization and summarizes our current knowledge about the substructure of prion protein amyloid fibrils.

机译：ion病毒疾病的发现和仅蛋白质的of病毒传播假说的建立引起了人们对被称为构象性疾病的疾病的浓厚兴趣。尽管在阐明与构象障碍有关的几种淀粉样蛋白和肽的聚合机理并解决其原纤维3D结构方面已取得了重大进展，但已证明对病毒蛋白淀粉样蛋白原纤维及其聚合机理的研究非常困难。本篇综述介绍了支链反应的机理，以描述病毒聚合的特殊动力学，并总结了我们目前对knowledge病毒蛋白淀粉样蛋白亚结构的了解。

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《The FEBS journal》 |2007年第15期|共10页
作者
Baskakov IV;
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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
annyloid fibrils; branched-chain mechanism; in vitro conversion; polymerization kinetics; prion diseases; prion protein; CREUTZFELDT-JAKOB-DISEASE; IN-VITRO CONVERSION; SYNTHETIC PRIONS; SCRAPIE PRIONS; RESISTANT; PRPSC; TRANSMISSION; PROPAGATION; AGENT; AMPLIFICATION;

机译：淀粉样原纤维;支链机理;体外转化;聚合动力学;pr病毒疾病;pr病毒蛋白;CREUTZFELDT-雅各布病;体外转化;合成S;脂;抗性;PRPSC;传递;传播;试剂;扩增;

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专利

1. Branched chain mechanism of polymerization and ultrastructure of prion protein amyloid fibrils [J] . Baskakov IV The FEBS journal . 2007,第15期

机译：ion病毒蛋白淀粉样原纤维聚合和超微结构的支链机理
2. Ultrastructure and pathology of prion protein amyloid accumulation and cellular damage in extraneural tissues of scrapie-infected transgenic mice expressing anchorless prion protein [J] . Race Brent, Jeffrey Martin, McGovern Gillian, Prion . 2017,第4期

机译：朊病毒感染转基因小鼠外耳蛋白淀粉样蛋白淀粉样蛋白积累和细胞损伤的超微结构和病理学
3. Synthetic amyloid fibrils generated from the N-terminal prion protein fragment 23-144 cause transmissible prion disease in mice [J] . Choi Jin-Kyu, Cali Ignazio, Surewicz Krystyna, Prion . 2015,第Suppla1期

机译：由N末端pr病毒蛋白片段23-144产生的合成淀粉样蛋白原纤维导致小鼠传播性ion病毒疾病
4. DETECTION AND CHARACTERIZATION OF AMYLOID LIGHT CHAIN PROTEINS FROM FIBRILS [C] . Zhenning Hong, Roger Theberge, Yan Jiang, ASMS Conference on Mass Spectrometry and Allied Topics . 2007

机译：原纤维淀粉样蛋白轻链蛋白的检测与表征
5. Molecular architecture of amyloid forming peptides: Amyloid-beta (1--42) and prion protein (118--135). [D] . Ahmed, Mahiuddin. 2009

机译：淀粉样蛋白形成肽的分子结构：β-淀粉样蛋白（1-42）和病毒蛋白（118--135）。
6. Ultrastructure and pathology of prion protein amyloid accumulation and cellular damage in extraneural tissues of scrapie-infected transgenic mice expressing anchorless prion protein [O] . Brent Race, Martin Jeffrey, Gillian McGovern, 2017

机译：scrap病毒感染的表达无锚病毒蛋白的转基因小鼠神经外组织中of病毒蛋白淀粉样蛋白积累和细胞损伤的超微结构和病理
7. Branched chain mechanism of polymerization and ultrastructure of prion protein amyloid fibrils [O] . Ilia V. Baskakov 2007

机译：朊病毒蛋白淀粉样蛋白淀粉样蛋白淀粉样蛋白淀粉样蛋白淀粉样蛋白淀粉样蛋白淀粉样蛋白的分支机制

Branched chain mechanism of polymerization and ultrastructure of prion protein amyloid fibrils

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