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首页> 外文期刊>The FEBS journal >Apoptosis and autophagy: Targeting autophagy signalling in cancer cells -'trick or treats'
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Apoptosis and autophagy: Targeting autophagy signalling in cancer cells -'trick or treats'

机译：细胞凋亡和自噬：靶向癌细胞中的自噬信号-“捣蛋”

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Macroautophagy (hereafter referred to as autophagy) is a tightly regulated lysosome-dependent catabolic pathway. During this process, cytosolic constituents are sequestered into autophagosomes, which subsequently fuse with lysosomes to become autolysosomes, where their contents are degraded. Autophagy contributes to the maintenance of the cellular energy homeostasis, to the clearance of damaged organelles and to adaptation to environmental stresses. Accordingly, autophagy defects have been linked to a wide range of human pathologies, including cancer. The recent discovery of several evolutionarily conserved genes involved in autophagosome formation has greatly stimulated the autophagy research, and the complex signalling networks regulating mammalian autophagy have begun to emerge. Here, we draw the current picture of signalling pathways connecting mitogenic and stress-induced signals to the initiation and maturation of autophagosomes and discuss the possibilities of their targeting as therapeutic adjuvants in anticancer therapy.
机译：巨自噬（以下称为自噬）是严格调控的溶酶体依赖性分解代谢途径。在此过程中，胞质成分被隔离成自噬体，随后与溶酶体融合成为自溶体，其内容物被降解。自噬有助于维持细胞能量的动态平衡，清除受损的细胞器并适应环境压力。因此，自噬缺陷已与包括癌症在内的多种人类病理因素联系在一起。最近发现了与自噬小体形成有关的几个进化保守基因，极大地刺激了自噬的研究，调节哺乳动物自噬的复杂信号网络已经开始出现。在这里，我们绘制了将有丝分裂和应激诱导的信号连接到自噬体的启动和成熟的信号通路的当前图景，并讨论了将其靶向作为抗癌治疗辅助剂的可能性。

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