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首页> 外文期刊>The FEBS journal >The mitochondrial protein frataxin is essential for heme biosynthesis in plants.
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The mitochondrial protein frataxin is essential for heme biosynthesis in plants.

机译：线粒体蛋白frataxin对植物血红素的生物合成至关重要。

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摘要

Frataxin, a conserved mitochondrial protein implicated in cellular iron homeostasis, has been involved as the iron chaperone that delivers iron for the Fe-S cluster and heme biosynthesis. However, its role in iron metabolism remains unclear, especially in photosynthetic organisms. In previous work, we found that frataxin deficiency in Arabidopsis results in decreased activity of the mitochondrial Fe-S proteins aconitase and succinate dehydrogenase, despite the increased expression of the respective genes, indicating an important role for Arabidopsisthaliana frataxin homolog (AtFH). In this work, we explore the hypothesis that AtFH can participate in heme formation in plants. For this purpose, we used two Arabidopsis lines, atfh-1 and as-AtFH, with deficiency in the expression of AtFH. Both lines present alteration in several transcripts from the heme biosynthetic route with a decrease in total heme content and a deficiency in catalase activity that was rescued with the addition of exogenous hemin. Our data substantiate the hypothesis that AtFH, apart from its role in protecting bioavailable iron within mitochondria and the biogenesis of Fe-S groups, also plays a role in the biosynthesis of heme groups in plants.
机译：Frataxin是一种与细胞铁稳态有关的保守的线粒体蛋白，已被作为铁伴侣来为Fe-S团簇和血红素生物合成输送铁。但是，其在铁代谢中的作用仍不清楚，尤其是在光合生物中。在以前的工作中，我们发现拟南芥中的frataxin缺乏症导致线粒体Fe-S蛋白乌头酸酶和琥珀酸脱氢酶的活性降低，尽管各个基因的表达增加，表明的重要作用>拟南芥（Arabidopsisthaliana） frataxin同系物（AtFH）。在这项工作中，我们探讨了AtFH可以参与植物血红素形成的假设。为此，我们使用了两个拟南芥系， atfh-1 和as-AtFH，但AtFH的表达缺乏。两种品系均表现出血红素生物合成途径的几种转录物的改变，总血红素含量降低，过氧化氢酶活性不足，这可以通过添加外源血红​​素来挽救。我们的数据证实了以下假设：AtFH除了在保护线粒体内的生物利用铁和Fe-S基团的生物合成方面发挥作用外，还在植物血红素基团的生物合成中发挥作用。

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