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首页> 外文期刊>The FEBS journal >Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus. [Review]
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Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus. [Review]

机译：幽门螺杆菌Cag IV型分泌设备的组装和分子作用方式。 [评论]

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摘要

Bacterial type IV secretion systems (T4SS) form supramolecular protein complexes that are capable of transporting DNA or protein substrates across the bacterial cell envelope and, in many cases, also across eukaryotic target cell membranes. Because of these characteristics, they are often used by pathogenic bacteria for the injection of host cell-modulating virulence factors. One example is the human pathogen Helicobacter pylori, which uses the Cag-T4SS to induce a pro-inflammatory response and multiple cytoskeletal and gene regulatory effects in gastric epithelial cells. Work in recent years has shown that the Cag-T4SS exhibits marked differences in relation to other systems, both with respect to the composition of its secretion apparatus and the molecular details of its secretion mechanisms. This review describes the molecular properties of the Cag-T4SS and compares these with prototypical systems of this family of protein transporters. Copyright 2011 The Author Journal compilation Copyright 2011 FEBS.
机译：细菌IV型分泌系统（T4SS）形成超分子蛋白质复合物，该复合物能够跨细菌细胞包膜以及在许多情况下跨真核靶细胞膜转运DNA或蛋白质底物。由于这些特性，它们通常被病原细菌用于注射宿主细胞调节性毒力因子。一个例子是人类病原体幽门螺杆菌，它使用Cag-T4SS诱导胃上皮细胞的促炎反应以及多种细胞骨架和基因调节作用。近年来的工作表明，Cag-T4SS与其他系统相比，在其分泌装置的组成及其分泌机制的分子细节方面均表现出显着差异。这篇综述描述了Cag-T4SS的分子特性，并将其与该蛋白转运蛋白家族的原型系统进行了比较。版权所有2011作者期刊编辑版权所有2011 FEBS。

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