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首页> 外文期刊>The FEBS journal >2-Amino-nonyl-6-methoxyl-tetralin muriate activity against Candida albicans augments endogenous reactive oxygen species production - a microarray analysis study.
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2-Amino-nonyl-6-methoxyl-tetralin muriate activity against Candida albicans augments endogenous reactive oxygen species production - a microarray analysis study.

机译：2-氨基壬基-6-甲氧基-四氢化萘对白念珠菌的活性增加了内源性活性氧的产生-微阵列分析研究。

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Candida infections have become an increasingly significant problem, mainly because of the widespread nature of Candida and drug resistance. There is an urgent need to develop new classes of drugs for the treatment of opportunistic Candida infections, especially in medically complex patients. Previous studies have confirmed that 2-amino-nonyl-6-methoxyl-tetralin muriate (10b) possesses powerful antifungal activity in vitro against Candia albicans. To clarify the underlying action mechanism, an oligonucleotide microarray study was performed in C. albicans SC5314 without and with 10b treatment. The analytical results showed that energy metabolism-related genes, including glycolysis-related genes (PFK1, CDC19 and HXK2), fermentation-related genes (PDC11, ALD5 and ADH1) and respiratory electron transport chain-related genes (CBP3, COR1 and QCR8), were downregulated significantly. Functional analysis revealed that 10b treatment increased the generation of endogenous reactive oxygen species, and decreased mitochondrial membrane potential, ubiquinone-cytochrome c reductase (complexIII) activity and intracellular ATP levels in C. albicans SC5314. Also, addition of the antioxidant ascorbic acid reduced the antifungal activity of 10 b significantly. These results suggest that mitochondrial aerobic respiration shift and endogenous reactive oxygen species augmentation might contribute to the antifungal activity of 10b against C. albicans. This information may prove to be useful for the development of new strategies to treat Candida infections.Digital Object Identifier http://dx.doi.org/10.1111/j.1742-4658.2011.08021.x
机译：主要由于 Candida 的广泛性和耐药性， Candida 感染已成为一个日益严重的问题。迫切需要开发新的药物类别，以治疗机会性 Candida 感染，尤其是在医疗复杂的患者中。先前的研究已证实，2-氨基壬基-6-甲氧基四氢呋喃果酸酯（10b）在体外对白念珠菌具有强大的抗真菌活性。为了阐明潜在的作用机理，在iC中进行了寡核苷酸微阵列研究。白色和白色SC5314未经10b处理。分析结果表明，能量代谢相关基因包括糖酵解相关基因（ PFK1 ， CDC19 和 HXK2 ），发酵相关基因（ PDC11 ， ALD5 和 ADH1 ）和呼吸电子运输链相关基因（ CBP3 ， COR1 < / i>和 QCR8 ）被显着下调。功能分析表明，10b处理可增加内源性活性氧的产生，并降低线粒体膜电位，泛醌-细胞色素 c 还原酶（plexIII）活性和 C中的细胞内ATP水平。白色的 SC5314。此外，添加抗氧化剂抗坏血酸会显着降低10b的抗真菌活性。这些结果表明线粒体有氧呼吸移位和内源性活性氧的增加可能有助于10b对C的抗真菌活性。白色的。该信息可能被证明对开发治疗 Candida 感染的新策略很有用。数字对象标识符http://dx.doi.org/10.1111/j.1742-4658.2011.08021.x

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