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首页> 外文期刊>The FEBS journal >Lymphotoxin a induces apoptosis, necroptosis andinflammatory signals with the same potency as tumournecrosis factor
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Lymphotoxin a induces apoptosis, necroptosis andinflammatory signals with the same potency as tumournecrosis factor

机译：淋巴毒素a诱导凋亡，坏死性坏死和炎症信号，其功效与肿瘤坏死因子相同

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Both of the TNF superfamily ligands, TNF and LTa, can bind and signalthrough TNFR1 and TNFR2, yet mice mutant for each have different phenotypes.Part of this difference is because LTa but not TNF can activate HerpesVirus Entry Mediator and also heterotrimerise with LTb to activate LTbR,which is consistent with the similar phenotypes of the LTa and LTbR deficientmice. However, it has also been reported that the LTa3 homotrimer signals differentlythan TNF through TNFR1, and has unique roles in initiation and exacerbationof some inflammatory diseases. Our modeling of the TNF/TNFR1interface compared to the LTa3/TNFR1 structure revealed some differencesthat could affect signalling by the two ligands. To determine whether there wereany functional differences in the ability of TNF and LTa3 to induce TNFR1-dependent apoptosis or necroptosis, and if there were different requirements forcIAPs and Sharpin to transmit the TNFR1 signal, we compared the ability ofcells to respond to TNF and LTa3. Contrary to our hypothesis, we were unableto discover differences in signalling by TNFR1 in response to TNF and LTa3.Our results imply that the reasons for the conservation of LTa are most likelydue either to differential regulation, the ability to signal through Herpes VirusEntryMediator or the ability of LTa to form heterotrimers with LTb.
机译：TNF超家族的两个配体TNF和LTa都可以结合并通过TNFR1和TNFR2进行信号传递，但每种突变体的小鼠都有不同的表型。 LTbR，与LTa和LTbR缺陷小鼠的相似表型一致。但是，据报道，LTa3同型三聚体的信号传导与TNFR1通过TNFR1不同，并且在某些炎症性疾病的发作和恶化中具有独特作用。与LTa3 / TNFR1结构相比，我们对TNF / TNFR1接口的建模揭示了一些可能影响两个配体信号传导的差异。为了确定TNF和LTa3诱导TNFR1依赖性细胞凋亡或坏死病的能力是否存在功能差异，以及是否对cIAPs和Sharpin传递TNFR1信号的要求不同，我们比较了细胞对TNF和LTa3应答的能力。与我们的假设相反，我们无法发现TNFR1对TNF和LTa3应答的信号传导差异。我们的结果表明，保留LTa的原因很可能是由于差异调节，通过疱疹VirusEntryMediator发出信号的能力或与LTb形成异源三聚体。

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