Acetylcholinesterase in cell adhesion, neurite growth and network formation

Paraoanu LE; Layer PG

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Acetylcholinesterase in cell adhesion, neurite growth and network formation

机译：乙酰胆碱酯酶在细胞粘附，神经突生长和网络形成中的作用

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The expression of acetylcholinesterase is not restricted to cholinergically innervated tissues and relates to both neurotransmission and multiple biological aspects, including neural development, stress response and neurodegenerative diseases. Therefore, the classical function of acetylcholinesterase has to be distinguished from its non-classical, e.g. enzymatic from non-enzymatic, functions. Here, the roles of acetylcholinesterase in cell adhesion, promoting neurite outgrowth and neural network formation are reviewed briefly, together with potential mechanisms to support these functions. Part of these functions may depend on the structural properties of acetylcholinesterase, for example, protein-protein interactions. Recent findings have revealed that laminin-1 is an interaction partner for acetylcholinesterase. The binding of acetylcholinesterase to this extracellular matrix component may allow cell-to-cell recognition, and also cell signalling via membrane receptors. Studies using monolayer and 3D spheroid retinal cultures, as well as the acetylcholinesterase-knockout mouse, have been instrumental in elaborating the non-classical functions of acetylcholinesterase.

机译：乙酰胆碱酯酶的表达不仅限于胆碱能神经支配的组织，而且涉及神经传递和多种生物学方面，包括神经发育，应激反应和神经退行性疾病。因此，必须将乙酰胆碱酯酶的经典功能与其非经典功能区分开来，例如乙酰胆碱酯酶。从非酶促酶的功能。在这里，简要回顾了乙酰胆碱酯酶在细胞粘附，促进神经突向外生长和神经网络形成中的作用，以及支持这些功能的潜在机制。这些功能的一部分可能取决于乙酰胆碱酯酶的结构特性，例如蛋白质-蛋白质相互作用。最近的发现表明层粘连蛋白-1是乙酰胆碱酯酶的相互作用伴侣。乙酰胆碱酯酶与该细胞外基质组分的结合可以允许细胞对细胞的识别，以及通过膜受体的细胞信号传导。使用单层和3D球形视网膜培养物以及乙酰胆碱酯酶敲除小鼠进行的研究在阐明乙酰胆碱酯酶的非经典功能中起了重要作用。

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《The FEBS journal》 |2008年第4期|共7页
作者
Paraoanu LE; Layer PG;
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正文语种 eng
中图分类生物化学;
关键词
acetylcholinesterase; adhesion; co-opting proteins; extracellular matrix; knock-out mouse; neurite outgrowth; non-cholinergic functions; laminin-1; retina; structural interactions; AMYLOID-BETA-PEPTIDE; EARLY CHICKEN BRAIN; EXPRESSION; LAMININ; CHOLINESTERASES; DIFFERENTIATION; OUTGROWTH; PROTEINS; NEURONS; BUTYRYLCHOLINESTERASE;

机译：乙酰胆碱酯酶;粘附;选择蛋白;细胞外基质;敲除小鼠;神经突向外生长;非胆碱能功能;laminin-1;视网膜;结构相互作用;淀粉样多肽;早期鸡脑;表达;层粘连蛋白;胆碱;分化;生长;蛋白质;神经元;丁酰胆碱酯酶;

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1. Acetylcholinesterase in cell adhesion, neurite growth and network formation [J] . Paraoanu LE, Layer PG The FEBS journal . 2008,第4期

机译：乙酰胆碱酯酶在细胞粘附，神经突生长和网络形成中的作用
2. The intracellular portion of GITR enhances NGF-promoted neurite growth through an inverse modulation of Erk and NF-???oB signalling The intracellular portion of GITR enhances NGF-promoted neurite growth through an inverse modulation of Erk and NF-???oB signalling The intracellular portion of GITR enhances NGF-promoted neurite growth through an inverse modulation of Erk and NF-???oB signalling [J] . Alun M. Davies, Giuseppe Nocentini, Laura McKelvey, Biology Open . 2012,第10期

机译：GITR的细胞内部分通过Erk和NF-κB信号的反向调节增强NGF促进的神经突生长。GITR的细胞内部分通过Erk和NF-κB信号的反向调节增强NGF促进的神经突生长。 GITR的细胞内部分通过Erk和NF-κB信号转导的反向调节增强NGF促进的神经突生长。
3. Immunocytochemical evidence for colocalization in neurite growth cones of actin and myosin and their relationship to cell-substratum adhesions☆ [J] . Paul C. Letourneau Developmental biology . 1981,第1期

机译：肌动蛋白和肌球蛋白神经突生长锥共定位的免疫细胞化学证据及其与细胞-基质粘附的关系☆
4. Femtosecond laser-assisted estimation of time evolution of cell-cell adhesion force between neurite and mast cell [C] . Iino Takanori, Hagiyama Man, Furuno Tadahide, Conference on Lasers and Electro-Optics Pacific Rim . 2013

机译：飞秒激光辅助估计神经突与肥大细胞之间细胞间粘附力的时间演变
5. Hepatocyte Growth Factor-Preconditioned Neural Progenitor Cells Attenuate Astrocyte Reactivity and Promote Neurite Outgrowth [D] . Dragas, Rachel. 2018

机译：肝细胞生长因子 - 预处理神经祖细胞衰减星形胶质细胞反应性，促进神经突的产卵
6. Neurite Outgrowth Stimulated by Neural Cell Adhesion Molecules Requires Growth-Associated Protein-43 (GAP-43) Function and Is Associated with GAP-43 Phosphorylation in Growth Cones [O] . Karina F. Meiri, Jane L. Saffell, Frank S. Walsh, 1998

机译：神经细胞粘附分子刺激的神经突生长需要生长相关蛋白43（GAP-43）功能并与生长锥中的GAP-43磷酸化相关。
7. Acetylcholinesterase in cell adhesion, neurite growth and network formation [O] . Laura E. Paraoanu, Paul G. Layer 2008

机译：乙酰胆碱酯酶在细胞粘附，神经突生长和网络形成中
8. Sulfur Mustards Induce Neurite Extension and Acetylcholinesterase Synthesis in Cultured Neuroblastoma Cells. [R] . Lanks, K. W., Turnbull, J. D., Aloyo, V. J., 1974

机译：硫芥子诱导培养的神经母细胞瘤细胞中的神经突延伸和乙酰胆碱酯酶合成。

Acetylcholinesterase in cell adhesion, neurite growth and network formation

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