...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The FEBS journal >Adhesion properties of adhesion-regulating molecule 1 protein on endothelial cells.
【24h】

Adhesion properties of adhesion-regulating molecule 1 protein on endothelial cells.

机译：粘附调节分子1蛋白在内皮细胞上的粘附特性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Numerous adhesion molecules have been described, and the molecular mechanisms of lymphocyte trafficking across the endothelium is starting to be elucidated. Identification of the molecules involved in the organoselectivity of this process would help in the targeting of drug therapy to specific tissues. Adhesion-regulating molecule-1 (ARM-1) is an adhesion-regulating molecule previously identified on T cells. It does not belong to any known families of adhesion molecules. In this study, we show the presence of ARM-1 in endothelial cells, the adhesion partners of lymphocytes. ARM-1 mRNA was found to be differentially expressed in endothelial cell lines of various tissue origin and lymphocyte cell lines. Interestingly, ARM-1 is absent from skin endothelial cells. In our assay, skin endothelial cells display a distinct capacity to mediate adhesion of activated T lymphocytes. Overexpression of ARM-1 in skin endothelial cells increased adhesion of CEMT4 and NK lymphocytes, confirming that ARM-1 also regulates adhesion in endothelial cells. We also show that ARM-1 is a cytosolic protein associated with the plasma membrane. However, no cell surface expression of the protein was observed. These results suggest an indirect role of ARM-1 in adhesion rather than a direct role as an adhesion molecule itself.
机译：已经描述了许多粘附分子，并且已经阐明了淋巴细胞跨内皮运输的分子机制。鉴定涉及该过程的有机选择性的分子将有助于将药物疗法靶向特定组织。粘附调节分子1（ARM-1）是先前在T细胞上鉴定的粘附调节分子。它不属于任何已知的粘附分子家族。在这项研究中，我们显示了内皮细胞（淋巴细胞的粘附伴侣）中ARM-1的存在。发现ARM-1 mRNA在各种组织起源的内皮细胞系和淋巴细胞系中差异表达。有趣的是，皮肤内皮细胞中没有ARM-1。在我们的测定中，皮肤内皮细胞显示出介导活化T淋巴细胞粘附的独特能力。皮肤内皮细胞中ARM-1的过表达增加了CEMT4和NK淋巴细胞的粘附，这证明ARM-1也调节内皮细胞中的粘附。我们还表明，ARM-1是与质膜相关的胞质蛋白。但是，没有观察到蛋白质的细胞表面表达。这些结果表明ARM-1在粘附中起间接作用，而不是作为粘附分子本身起直接作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号