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首页> 外文期刊>The FEBS journal >Structural and mechanistic aspects of flavoproteins: photosynthetic electron transfer from photosystem I to NADP
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Structural and mechanistic aspects of flavoproteins: photosynthetic electron transfer from photosystem I to NADP

机译：黄素蛋白的结构和机制方面：光合电子从光系统I转移到NADP

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This minireview covers the research carried out in recent years into different aspects of the function of the flavoproteins involved in cyanobacterial photosynthetic electron transfer from photosystem I to NADP, flavodoxin and ferredoxin-NADP reductase. Interactions that stabilize protein-flavin complexes and tailor the midpoint potentials in these proteins, as well as many details of the binding and electron transfer to protein and ligand partners, have been revealed. In addition to their role in photosynthesis, flavodoxin and ferredoxin-NADP reductase are ubiquitous flavoenzymes that deliver NAD(P)H or low midpoint potential one-electron donors to redox-based metabolisms in plastids, mitochondria and bacteria. They are also the basic prototypes for a large family of diflavin electron transferases with common functional and structural properties. Understanding their mechanisms should enable greater comprehension of the many physiological roles played by flavodoxin and ferredoxin-NADP reductase, either free or as modules in multidomain proteins. Many aspects of their biochemistry have been extensively characterized using a combination of site-directed mutagenesis, steady-state and transient kinetics, spectroscopy and X-ray crystallography. Despite these considerable advances, various key features of the structural-function relationship are yet to be explained in molecular terms. Better knowledge of these systems and their particular properties may allow us to envisage several interesting applications of these proteins beyond their physiological functions.
机译：这份简短的综述涵盖了近年来对参与蓝细菌光合电子从光系统I到NADP，黄酮毒素和铁氧还蛋白-NADP还原酶转移的黄素蛋白功能不同方面的研究。已经揭示了稳定蛋白质-黄素复合物并调整这些蛋白质中点电位的相互作用，以及与蛋白质和配体伙伴结合和电子转移的许多细节。黄酮毒素和铁氧还蛋白-NADP还原酶除了在光合作用中发挥作用外，还普遍存在，将NAD（P）H或低中点潜在的单电子供体传递给质体，线粒体和细菌中基于氧化还原的代谢。它们也是具有共同功能和结构特性的大分子黄素电子转移酶家族的基本原型。理解它们的机制应该能够更好地理解黄素毒素和铁氧还蛋白-NADP还原酶的自由或作为多域蛋白的模块所起的许多生理作用。通过定点诱变，稳态和瞬态动力学，光谱学和X射线晶体学相结合，已广泛表征了其生物化学的许多方面。尽管取得了这些相当大的进步，但结构-功能关系的各种关键特征仍需用分子学来解释。对这些系统及其特殊性质的更好的了解可能使我们能够设想这些蛋白质超出其生理功能的几种有趣的应用。

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