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首页> 外文期刊>The FEBS journal >The Theodor Bucher Lecture - Calcium - a universal carrier of biological signals - Delivered on 3 July 2003 at the Special FEBS Meeting in Brussels
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The Theodor Bucher Lecture - Calcium - a universal carrier of biological signals - Delivered on 3 July 2003 at the Special FEBS Meeting in Brussels

机译：Theodor Bucher讲座-钙-一种生物信号的通用载体-2003年7月3日在布鲁塞尔举行的FEB​​S特别会议上发表

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Calcium is the most universal carrier of signals to cells. Chosen by evolution because of its peculiar flexibility as a ligand, it now regulates all important aspects of cell activity, beginning with the creation of new life at fertilization and ending with the dramatic event of apoptotic suicide at the end of the life cycle. The process of signal transduction by Ca2+ displays a number of properties that make it unique among all other carriers of signals: for instance, the ability to perform both a first messenger and a 24 second messenger function, or the frequent activation of autoregulatory mechanisms. The aspect that distinguishes the Ca2+ signaling function most dramatically is ambivalence. Cells have an absolute dependence on the messenger function of Ca2+ in order to function properly and must control its homeostasis with precision to maintain its free concentration in their interior at the appropriate low level. Catastrophy, however, invariably follows whenever protracted failures of the control mechanisms lead to sustained Ca2+ overload.
机译：钙是细胞信号的最通用载体。由于其作为配体的特殊灵活性而被进化所选择，它现在调节细胞活性的所有重要方面，从受精时创造新生命开始，到生命周期结束时发生凋亡性自杀这一戏剧性事件结束。 Ca2 +进行信号转导的过程显示出许多使其在所有其他信号载体中都独一无二的特性：例如，既可以执行第一信使和​​24秒信使功能，又可以频繁激活自动调节机制。最显着区分Ca2 +信号传导功能的方面是矛盾性。细胞对Ca2 +的信使功能具有绝对依赖性，以使其正常运行，并且必须精确控制其稳态，以将其在体内的自由浓度维持在适当的低水平。但是，每当控制机构的长期失败导致持续的Ca2 +超负荷时，都会发生灾难性的灾难。

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