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首页> 外文期刊>The FEBS journal >Nuclear inositide specific phospholipase Csignalling – interactions and activity
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Nuclear inositide specific phospholipase Csignalling – interactions and activity

机译：核苷特定磷脂酶信号转导–相互作用和活性

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摘要

Evidence accumulated over the past 20 years has highlighted the presenceof an autonomous nuclear inositol lipid metabolism, and suggests that lipidsignalling molecules are important components of signalling pathwaysoperating within the nucleus. Nuclear polyphosphoinositide (PI) signallingrelies on the synthesis and metabolism of phosphatidylinositol 4,5-bisphosphate,which can modulate the activity of effector proteins and is a substrateof signalling enzymes. The regulation of the nuclear PI pool istotally independent from the plasma membrane counterpart, suggestingthat the nucleus constitutes a functionally distinct compartment of inositollipids metabolism. Among the nuclear enzymes involved in PI metabolism,inositide specific phospholipase C (PI-PLC) has been one of the mostextensively studied. Several isoforms of PI-PLCs have been identified in thenucleus, namely PI-PLC-b1, c1, d1 and f; however, the b1 isozyme is thebest characterized. In the present review, we focus on the signal transduction-related metabolism of nuclear PI-PLC and review the most convincingevidence for PI-PLC expression and activity being involved in differentiationand proliferation programmes in several cell systems. Moreover,nuclear PI-PLC is an intermediate effector and interactor for nuclear inositidesignalling. The inositide cycle exists and shows a biological role insidethe nucleus. It is an autonomous lipid-dependent signalling system, independentlyregulated with respect to the one at the plasma membrane counterpart,and is involved in cell cycle progression and differentiation.
机译：在过去的20年中积累的证据突显了自主核肌醇脂质代谢的存在，并表明脂质信号传递分子是细胞核内信号传导途径的重要组成部分。核聚磷酸肌醇（PI）信号转导依赖于磷脂酰肌醇4,5-双磷酸酯的合成和代谢，可调节效应蛋白的活性，是信号转导酶的底物。核PI池的调节完全独立于质膜对应物，表明核构成肌醇脂代谢的功能不同的区室。在参与PI代谢的核酶中，肌醇特异性磷脂酶C（PI-PLC）已成为研究最广泛的一种。在核中已鉴定出几种PI-PLC的同工型，即PI-PLC-b1，c1，d1和f。但是，b1同工酶的特征最为明显。在当前的审查中，我们集中于核PI-PLC的信号转导相关的代谢，并审查最有说服力的证据表明PI-PLC的表达和活性参与了几种细胞系统的分化和增殖程序。此外，核PI-PLC是核致癌设计的中间效应物和相互作用物。肌苷循环存在并在核内显示出生物学作用。它是一种自主的脂质依赖性信号传导系统，相对于质膜对应物是独立调节的，并且参与细胞周期的进展和分化。

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