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Mesoporous silica nanoparticles for the design of smart delivery nanodevices

机译：介孔二氧化硅纳米颗粒用于智能输送纳米器件的设计

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Mesoporous silica nanoparticles (MSNPs) are receiving growing attention by the scientific community for their groundbreaking potential in nanomedicine. It is possible to load huge amounts of cargo into the mesopore voids and capping the pore entrances with different nanogates. Different internal or external stimuli can provoke the nanocap removal and trigger the departure of the cargo, which permits the design of stimuli-responsive drug delivery nanodevices. It is also feasible to combine the multifunctionality of MSNPs with the wide range of applications of magnetic nanoparticles (mNPs), giving rise to advanced smart nanosystems whose features and functionality can be tailored attending to specific clinical needs. This review describes the possible combinations of MSNPs, stimuli-responsive nanocaps and mNPs and the current scientific challenges aimed at accelerating the progression from bench to bedside.
机译：介孔二氧化硅纳米颗粒（MSNP）由于其在纳米医学中的开创性潜力而受到科学界的日益关注。有可能将大量货物装载到中孔空隙中，并用不同的纳米门封闭孔口。不同的内部或外部刺激可引起纳米帽的去除并触发货物的离开，这允许设计刺激响应性药物递送纳米装置。将MSNP的多功能性与磁性纳米颗粒（mNP）的广泛应用相结合也是可行的，从而产生了先进的智能纳米系统，其特征和功能可以根据特定的临床需求进行定制。这篇综述描述了MSNP，刺激响应性纳米帽和mNP的可能组合以及当前旨在加速从板凳到床边的科学挑战。

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