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首页> 外文期刊>Biomaterials Science >Thixotropic silk nanofibril-based hydrogel with extracellular matrix-like structure
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Thixotropic silk nanofibril-based hydrogel with extracellular matrix-like structure

机译：触变丝纳米原纤维基水凝胶，具有细胞外基质样结构

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摘要

Silk fibroin (SF) based materials have been widely studied and applied in bio-related areas due to their excellent structural and biological properties. Here, we present an injectable hydrogel formed by SF nanofibrils via simple fibrillation and centrifugation approach. The hydrogels with extracellular matrix-like structure not only perform the sufficient mechanical properties, but also show outstanding thixotropic character, whose storage modulus (G') can recover to 93% within 40 seconds after a large shearing strain (5000 %). More importantly, the injectable hydrogel exhibits significant biocompatibility for L929 cells cultured in hydrogel after injection, illustrated by cell viability and cytotoxicity assays. All of these results indicate that such SF nanofibril-based hydrogel has promise in application such as a cell therapy carrier.
机译：基于丝素蛋白（SF）的材料因其出色的结构和生物学特性而被广泛研究并应用于生物相关领域。在这里，我们介绍了由SF纳米原纤维通过简单的原纤化和离心方法形成的可注射水凝胶。具有细胞外基质状结构的水凝胶不仅具有足够的机械性能，而且还具有出色的触变性，其储能模量（G'）在大剪切应变（5000％）后的40秒内可以恢复到93％。更重要的是，注射后的水凝胶对注射后在水凝胶中培养的L929细胞显示出显着的生物相容性，这通过细胞活力和细胞毒性试验得以说明。所有这些结果表明，这种基于SF纳米原纤维的水凝胶在诸如细胞治疗载体的应用中具有前景。

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