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首页> 外文期刊>The Indian journal of tuberculosis >INFLUENCE OF DRUG SUSCEPTIBILITY ON TREATMENT OUTCOME AND SUSCEPTIBILITY PROFILE OF 'FAILURES' TO CATEGORY II REGIMEN
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INFLUENCE OF DRUG SUSCEPTIBILITY ON TREATMENT OUTCOME AND SUSCEPTIBILITY PROFILE OF 'FAILURES' TO CATEGORY II REGIMEN

机译：药物敏感性对II类方案“失败”的治疗结果和易感性的影响

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摘要

Objective: To assess the influence of drag resistance on treatment outcome among patients treated with Category-II regimen and document drug susceptibility pattern of "Failures" to this regimen.Design: A retrospective analysis of patients registered from May 1999 through December 2004.Results: Treatment success was 42% among 572 patients and was similar among patients with fully susceptible or resistant but non-MDR organisms (41% of 254 and 40% of 128 patients, respectively). Among 49 MDR-TB patients, 27% had successful treatment outcome. The failure rates among patients with fully susceptible, resistant but non-MDR and MDR bacilli, were 6%,12% and 27% respectively. Default was significantly higher among males (53% vs.34%: p<0.01) smokers (57% vs., 36%: p 0.001), alcoholics (58% vs.. 39%: p <0 001) and patients with higher initial smear grading (2+ or 3+, 56% vs. scanty or 1+,44%: p <0.01). DST results were available for 60% (31 of 52) of failures and 10 had MDR-TB.Conclusion: The low success rate to the re-treatment regimen was mainly due to non-compliance Failure was observed among 9% of patients and MDR-TB was 32% among Category II failures. The currently recommended Category II regimen appears to be adequate for majority of re-treatment cases.
机译：目的：评估阻力阻力对II类方案治疗患者的治疗效果的影响，并记录该方案“失败”的药物敏感性模式。设计：回顾性分析1999年5月至2004年12月注册的患者。在572例患者中，治疗成功率为42％，在完全易感或耐药但非耐多药生物体的患者中，治疗成功率相似（分别为254％患者和254患者中的41％和128％）。在49名耐多药结核病患者中，有27％的治疗结果成功。完全易感，耐药但非耐多药和耐多药杆菌的患者的失败率分别为6％，12％和27％。男性吸烟者（53％vs.34％：p <0.01），吸烟者（57％vs. 36％：p 0.001），酗酒者（58％vs. 39％：p <0.001）的违约率明显更高较高的初始涂片分级（2+或3+，56％vs.稀疏或1 +，44％：p <0.01）。 DST结果可用于60％的失败（52例中的31例）和10例MDR-TB。结论：重新治疗方案的成功率低主要是由于不依从性在9％的患者和MDR中观察到失败-TB在II类故障中占32％。目前推荐的II类治疗方案似乎适合大多数再治疗病例。

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