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首页> 外文期刊>Biomaterials Science >On-demand generation of singlet oxygen from a smart graphene complex for the photodynamic treatment of cancer cells
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On-demand generation of singlet oxygen from a smart graphene complex for the photodynamic treatment of cancer cells

机译：从智能石墨烯络合物按需生成单线态氧以用于光动力治疗癌细胞

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Graphene oxide (GO) has been proven to be a highly efficient long-range quencher for various fluorescence processes, which intrinsically work through a photophysical mechanism similar to that of singlet oxygen generation (SOG). Under our hypothesis that GO may be capable of quenching the SOG process, here we design and synthesize a novel nanocomplex consisting of GO, a photosensitizer and an aptamer. We demonstrate that GO is an ideal SOG controller, which can reversibly quench and recover SOG depending on the interaction intensity between GO and a photosensitizer. Additionally, it can simultaneously act as a carrier for the efficient loading and delivery of the photosensitizers to cancer cells. Thus, during the delivery process, SOG of the nanocomplex can be completely inhibited by the quenching capacity of the GO even though there is light present; however, when the nanocomplex enters into cancer cells where target molecules are present, SOG is triggered by a target binding event and singlet oxygen is reversibly released from the nanocomplex, ultimately inducing significant cell death in the presence of light. This proof-of-concept study provides a new chemical strategy for creating a highly selective photodynamic therapy with low toxicity, using hydrophilic GO-based systems.
机译：氧化石墨烯（GO）已被证明是用于各种荧光过程的高效远程淬灭剂，其本质上是通过类似于单线态氧生成（SOG）的光物理机制起作用的。在我们GO可能能够淬灭SOG过程的假设下，在这里我们设计并合成了由GO，光敏剂和适体组成的新型纳米复合物。我们证明GO是理想的SOG控制器，它可以根据GO和光敏剂之间的相互作用强度可逆地淬灭和回收SOG。另外，它可以同时充当将光敏剂有效负载和递送至癌细胞的载体。因此，在递送过程中，即使存在光，纳米复合物的SOG也可以被GO的淬灭能力完全抑制。然而，当纳米复合物进入存在靶分子的癌细胞时，SOG由靶结合事件触发，单线态氧可逆地从纳米复合物中释放出来，最终在有光的情况下导致大量细胞死亡。这项概念验证研究提供了一种新的化学策略，可以使用基于亲水性GO的系统创建具有低毒性的高选择性光动力疗法。

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