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首页> 外文期刊>The British Journal of Nutrition >Fatty acid desaturase 2 (FADS2) insertion/deletion polymorphism impact on muscle fatty acid profile in European grayling (Thymallus thymallus).
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Fatty acid desaturase 2 (FADS2) insertion/deletion polymorphism impact on muscle fatty acid profile in European grayling (Thymallus thymallus).

机译：脂肪酸去饱和酶2（FADS2）插入/缺失多态性对欧洲河豚（Thymallus thymallus）肌肉脂肪酸谱的影响。

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摘要

An insertion (In)/deletion (Del) polymorphism in the fatty acid desaturase 2 (FADS2) gene, which codes for Delta 6-desaturase, was for the first time observed in fish. The polymorphism is located in the seventh intron of FADS2 and the insertion consists of eleven repeats of CTGT (44 bp) with an allelic frequency, for the insertion, of 39%. The polymorphism was associated with a modulation in Delta 6-desaturase activity as significant effects on the ratio of EPA or DHA to their precursors were found (P<0.001). A different distribution of SFA, MUFA and PUFA among the In/In, In/Del and Del/Del groups was also detected in fish fillet. The results suggest that genetic selection for this marker might improve the ability of European grayling to utilise dietary n-3 long-chain PUFA precursors, as Delta 6-desaturase is the rate-limiting enzyme in the production of EPA and DHA from alpha -linolenic acid.
机译：在鱼类中首次观察到脂肪酸脱氢酶2（FADS2）基因的插入（In）/缺失（Del）多态性，该基因编码Delta 6-去饱和酶。该多态性位于FADS2的第七个内含子中，并且插入由CTGT的11个重复（44bp）组成，对于插入，等位基因频率为39％。该多态性与δ6-去饱和酶活性的调节有关，因为发现其对EPA或DHA与其前体的比率具有显着影响（P <0.001）。在鱼片中还检测到In / In，In / Del和Del / Del组中SFA，MUFA和PUFA的不同分布。结果表明，对该标记的遗传选择可能会提高欧洲河豚利用膳食n-3长链PUFA前体的能力，因为Delta 6-去饱和酶是α-亚麻酸生产EPA和DHA的限速酶酸。

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