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首页> 外文期刊>The British Journal of Nutrition >Dietary supplementation of trans-11-vaccenic acid reduces adipocyte size but neither aggravates nor attenuates obesity-mediated metabolic abnormalities in fa/fa Zucker rats.
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Dietary supplementation of trans-11-vaccenic acid reduces adipocyte size but neither aggravates nor attenuates obesity-mediated metabolic abnormalities in fa/fa Zucker rats.

机译：膳食补充反式-11癸酸可减少fa / fa Zucker大鼠的肥胖介导的代谢异常，但既不会加重也不会减弱。

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摘要

Conjugated linoleic acid (CLA) present in dairy and ruminant fat has beneficial effects on metabolic syndrome characteristics in humans and some rodent models. Production practices to increase the milk content of CLA are also substantially elevating trans-11-vaccenic acid (VA). Questions are being raised whether VA has the same beneficial actions as CLA or has adverse biological effects similar to industrially produced trans-fatty acids. The present study examined the effects of dietary supplementation of either 0 or 1.5 % (w/w) VA for 8 weeks on lipidaemia, glycaemia, blood pressure, hepatic steatosis, adipocyte size and molecular markers of inflammation and insulin signalling in fa/fa Zucker rats. Dietary supplementation of VA did not alter feed intake, weight gain, blood pressure or organ:body weight (BW) ratios, except the epididymal fat:BW ratio which was lower in the VA group compared with the control group. The total liver lipid concentration as an indicator of hepatic steatosis was not different between the groups. Likewise, there were no changes in fasting lipidaemia, glycaemia or oral glucose tolerance. Although there were no physiological differences observed between the groups, animals supplemented with VA had smaller adipocytes (approximately 7 % smaller than the controls). The VA group also had higher adipophilin and IL-10 protein levels in epididymal adipose tissue (1.7- and 1.4-fold higher than the controls, respectively); however, there were no changes observed in critical nodes of insulin signalling. The present study provides evidence that supplementation with VA, a naturally produced trans-fat, has some positive effects on adipose tissue and did not exacerbate obesity-mediated metabolic abnormalities
机译：乳制品和反刍动物脂肪中存在的共轭亚油酸（CLA）对人类和某些啮齿动物模型的代谢综合征特征具有有益的影响。增加CLA牛奶含量的生产实践也大大提高了反式11-庚酸（VA）。 VA是否具有与CLA相同的有益作用或类似于工业生产的反式脂肪酸具有不利的生物学作用，人们对此提出了疑问。本研究检查了饮食补充0或1.5％（w / w）VA连续8周对fa / fa Zucker中的血脂症，血糖，血压，肝脂肪变性，脂肪细胞大小以及炎症和胰岛素信号分子标记的影响大鼠。 VA的饮食补充没有改变饲料的摄入量，体重增加，血压或器官：体重（BW）比率，除了附睾脂肪：BW比率在VA组比对照组低。两组之间的总肝脂质浓度作为肝脂肪变性的指标没有差异。同样，空腹血脂，血糖或口服葡萄糖耐量也没有变化。尽管两组之间没有观察到生理差异，但是补充了VA的动物的脂肪细胞更小（比对照组小约7％）。 VA组在附睾脂肪组织中也具有更高的脂肪蛋白和IL-10蛋白水平（分别比对照组高1.7倍和1.4倍）。然而，在胰岛素信号的关键节点没有观察到变化。本研究提供了证据，补充天然产生的反式脂肪VA对脂肪组织有一些积极作用，并且不会加剧肥胖介导的代谢异常

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