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首页> 外文期刊>The British Journal of Nutrition >Dietary supplementation with tributyrin alleviates intestinal injury in piglets challenged with intrarectal administration of acetic acid.
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Dietary supplementation with tributyrin alleviates intestinal injury in piglets challenged with intrarectal administration of acetic acid.

机译：日粮中添加三丁酸甘油酯可减轻经直肠内施用乙酸攻击的仔猪的肠损伤。

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摘要

Tributyrin (TBU) is a good dietary source of butyrate and has beneficial effects on the maintenance of normal intestinal morphology. The present study tested the hypothesis that dietary TBU supplementation could alleviate intestinal injury in the acetic acid (ACA)-induced porcine model of colitis. A total of eighteen piglets (25 d old) were randomly allocated to one of three treatment groups (control, ACA and TBU). The control and ACA groups were fed a basal diet and the TBU group was fed the basal diet supplemented with 0.1% TBU. On day 15 of the trial, under anaesthesia, a soft catheter was inserted into the rectum of piglets (20-25 cm from the anus), followed by administration of either saline (control group) or ACA (10 ml of 10% ACA solution for ACA and TBU groups). On day 22 of the trial, after venous blood samples were collected, piglets were killed to obtain mid-ileum and mid-colon mucosae. Compared with the control group, the ACA group exhibited an increase (P<0.05) in lymphocyte counts, creatinine, PGE2, and malondialdehyde concentrations and diamine oxidase and inducible NO synthase activities in the plasma and lymphocyte density in the colon and a decrease in insulin concentrations and glutathione peroxidase activity, ileal villus height:crypt depth ratios and goblet cell numbers in the colon. These adverse effects of ACA were attenuated by TBU supplementation. Moreover, TBU prevented the ACA-induced increase in caspase-3 levels while enhancing claudin-1 protein and epidermal growth factor receptor (EGFR) mRNA expression in the colonic mucosa. Collectively, these results indicate that dietary supplementation with 0.1% TBU alleviates ACA-induced intestinal injury possibly by inhibiting apoptosis, promoting tight-junction formation and activating EGFR signalling.
机译：Tributyrin（TBU）是丁酸的良好饮食来源，对维持正常肠道形态具有有益作用。本研究检验了以下假设：在乙酸（ACA）诱导的猪结肠炎猪模型中，饮食中添加TBU可以减轻肠道损伤。将总共​​18头小猪（25天大）随机分配到三个治疗组（对照组，ACA和TBU）之一。对照组和ACA组接受基础饮食，TBU组基础饮食补充0.1％TBU。在试验的第15天，在麻醉下，将软导管插入仔猪的直肠（距肛门20-25厘米），然后给予生理盐水（对照组）或ACA（10 ml的10％ACA溶液） （针对ACA和TBU组）。在试验的第22天，收集静脉血样本后，杀死仔猪以获得回肠中段和结肠中段粘膜。与对照组相比，ACA组的血浆和淋巴细胞密度，淋巴细胞肌酐，PGE 2 ，丙二醛浓度，二胺氧化酶和可诱导的NO合酶活性增加（P <0.05）结肠中胰岛素浓度和谷胱甘肽过氧化物酶活性，回肠绒毛高度：隐窝深度比和结肠中杯状细胞数减少。补充TBU可减轻ACA的这些不良影响。此外，TBU防止了ACA诱导的caspase-3水平增加，同时增强了结肠黏膜中claudin-1蛋白和表皮生长因子受体（EGFR）mRNA的表达。总体而言，这些结果表明，饮食中添加0.1％TBU可能通过抑制细胞凋亡，促进紧密连接的形成并激活EGFR信号传导来减轻ACA诱导的肠道损伤。

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