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首页> 外文期刊>The British Journal of Nutrition >Dietary supplementation with beta-hydroxy-beta-methylbutyrate calcium during the early postnatal period accelerates skeletal muscle fibre growth and maturity in intra-uterine growth-retarded and normal-birth-weight piglets
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Dietary supplementation with beta-hydroxy-beta-methylbutyrate calcium during the early postnatal period accelerates skeletal muscle fibre growth and maturity in intra-uterine growth-retarded and normal-birth-weight piglets

机译：出生后早期在仔猪中添加β-羟基-β-甲基丁酸钙饮食可加速发育迟缓和正常体重的仔猪的骨骼肌纤维生长和成熟

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摘要

Intra-uterine growth restriction (IUGR) impairs postnatal growth and skeletal muscle development in neonatal infants. This study evaluated whether dietary beta-hydroxy-beta-methylbutyrate Ca (HMB-Ca) supplementation during the early postnatal period could improve muscle growth in IUGR neonates using piglets as a model. A total of twelve pairs of IUGR and normal-birth-weight (NBW) male piglets with average initial weights (1.85 (SEM 0.36) and 2.51 (SEM 0.39) kg, respectively) were randomly allotted to groups that received milk-based diets (CON) or milk-based diets supplemented with 800 mg/kg HMB-Ca (HMB) during days 7-28 after birth. Blood and longissimus dorsi (LD) samples were collected and analysed for plasma amino acid content, fibre morphology and the expression of genes related to muscle development. The results indicate that, regardless of diet, IUGR piglets had a significantly decreased average daily weight gain (ADG) compared with that of NBW piglets (P 0.05). However, IUGR piglets fed HMB-Ca had a net weight and ADG similar to that of NBW piglets fed the CON diet. Irrespective of body weight (BW), HMB-Ca supplementation markedly increased the type II fibre cross-sectional area and the mRNA expression of mammalian target of rapamycin (mTOR), insulin-like growth factor-1 and myosin heavy-chain isoform IIb in the LD of piglets (P 0.05). Moreover, there was a significant interaction between the effects of BW and HMB on mTOR expression in the LD (P 0.05). In conclusion, HMB-Ca supplementation during the early postnatal period could improve skeletal muscle growth and maturity by accelerating fast-twitch glycolytic fibre development in piglets.
机译：宫内生长受限（IUGR）会损害新生儿的产后生长和骨骼肌发育。这项研究使用仔猪作为模型，评估了出生后早期在饮食中添加β-羟基-β-甲基丁酸钙（HMB-Ca）是否可以改善IUGR新生儿的肌肉生长。随机将十二对平均初始体重（分别为1.85（SEM 0.36）和2.51（SEM 0.39）kg的IUGR和正常出生体重（NBW）雄性小猪）分配给接受以牛奶为基础的日粮的组（ CON）或以牛奶为基础的饮食，在出生后7-28天补充了800 mg / kg HMB-Ca（HMB）。收集血液和背最长肌（LD）样本，分析血浆氨基酸含量，纤维形态以及与肌肉发育相关的基因的表达。结果表明，无论哪种饮食，与NBW仔猪相比，IUGR仔猪的平均日增重（ADG）均显着降低（P <0.05）。但是，饲喂HMB-Ca的IUGR仔猪的净重和ADG与饲喂CON日粮的NBW仔猪相似。不考虑体重（BW），补充HMB-Ca可以显着增加II型纤维横截面积和哺乳动物雷帕霉素靶标（mTOR），胰岛素样生长因子-1和肌球蛋白重链同工型IIb的mRNA表达。仔猪的LD（P <0.05）。此外，BW和HMB对LD中mTOR表达的影响之间存在显着的相互作用（P <0.05）。总之，在产后早期补充HMB-Ca可通过促进仔猪快速抽搐糖酵解纤维的发育来改善骨骼肌的生长和成熟。

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