Syntheses of Glucose-Containing Lipid A Analogues and Their LPS-Antagonistic Activities

Masao Shiozaki; Hiromi Doi; Daisuke Tanaka; Takaichi Shimozato; Shin-ichi Kurakata

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Syntheses of Glucose-Containing Lipid A Analogues and Their LPS-Antagonistic Activities

机译：含葡萄糖的脂质A类似物的合成及其LPS拮抗活性

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Three anomeric pairs of lipid A-type disaccharides containing a glucose on their reducing end were synthesized,and their LPS-antagonistic activities were measured.The inhibitory activities (IC_50) on the LPS-induced TNFalpha production of these six compounds (16alpha,16beta,28alpha,28beta,40alpha,and 40beta) toward human whole blood cells were 0.35,0.42,2.37,1.16,2.89,and 7.70 nM,respectively.

机译：合成了三对异端对在其还原端含有葡萄糖的脂质A型二糖，并测量了它们的LPS拮抗活性。对这6种化合物（16alpha，16beta，对人类全血细胞的28alpha，28beta，40alpha和40beta）分别为0.35、0.42、2.37、1.16、2.89和7.70 nM。

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《Bulletin of the Chemical Society of Japan》 |2005年第6期|共14页
作者
Masao Shiozaki; Hiromi Doi; Daisuke Tanaka; Takaichi Shimozato; Shin-ichi Kurakata;
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正文语种 eng
中图分类化学;
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1. Syntheses of Glucose-Containing Lipid A Analogues and Their LPS-Antagonistic Activities [J] . Masao Shiozaki, Hiromi Doi, Daisuke Tanaka, Bulletin of the Chemical Society of Japan . 2005,第6期

机译：含葡萄糖的脂质A类似物的合成及其LPS拮抗活性
2. Synthesis of lipid A analogues containing glucose instead of glucosamine and their LPS-antagonistic activities [J] . Shiozaki M, Watanabe Y, Iwano Y, Tetrahedron . 2005,第21期

机译：含葡萄糖而不是氨基葡萄糖的脂质A类似物的合成及其LPS拮抗活性
3. Synthesis of lipid A analogues containing glucose instead of glucosamine and their LPS-antagonistic activities [J] . Shiozaki M, Watanabe Y, Iwano Y, Tetrahedron . 2005,第21期

机译：含葡萄糖而不是氨基葡萄糖的脂质A类似物的合成及其LPS拮抗活性
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Syntheses of Glucose-Containing Lipid A Analogues and Their LPS-Antagonistic Activities

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