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首页> 外文期刊>The British Journal of Nutrition >Reported zinc, but not copper, intakes influence whole-body bone density, mineral content and T score responses to zinc and copper supplementation in healthy postmenopausal women.
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Reported zinc, but not copper, intakes influence whole-body bone density, mineral content and T score responses to zinc and copper supplementation in healthy postmenopausal women.

机译：据报道，健康绝经后妇女摄入锌而不是铜会影响全身骨密度，矿物质含量和T值对补锌和补铜的反应。

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A supplementation trial starting with 224 postmenopausal women provided with adequate vitamin D and Ca was conducted to determine whether increased Cu and Zn intakes would reduce the risk for bone loss. Healthy women aged 51-80 years were recruited for a double-blind, placebo-controlled study. Women with similar femoral neck T scores and BMI were randomly assigned to two groups of 112 each that were supplemented daily for 2 years with 600 mg Ca plus maize starch placebo or 600 mg Ca plus 2 mg Cu and 12 mg Zn. Whole-body bone mineral contents, densities and T scores were determined biannually by dual-energy X-ray absorptiometry, and 5 d food diaries were obtained annually. Repeated-measures ANCOVA showed that bone mineral contents, densities and T scores decreased from baseline values to year 2. A priori contrasts between baseline and year 2 indicated that the greatest decreases occurred with Cu and Zn supplementation. Based on 5 d food diaries, the negative effect was caused by Zn and mainly occurred with Zn intakes >=8.0 mg/d. With Zn intakes <8.0 mg/d, Zn supplementation apparently prevented a significant decrease in whole-body bone densities and T scores. Food diaries also indicated that Mg intakes <237 mg/d, Cu intakes <0.9 mg/d and Zn intakes <8.0 mg/d are associated with poorer bone health. The findings indicate that Zn supplementation may be beneficial to bone health in postmenopausal women with usual Zn intakes <8.0 mg/d but not in women consuming adequate amounts of Zn
机译：一项补充试验从224名绝经后妇女提供了足够的维生素D和钙开始，以确定增加的铜和锌摄入量是否可以减少骨质流失的风险。招募年龄在51-80岁之间的健康女性进行双盲，安慰剂对照研究。股骨颈T评分和BMI相似的女性被随机分为两组，每组112人，在2年内每天补充600 mg Ca +玉米淀粉安慰剂或600 mg Ca + 2 mg Cu和12 mg Zn。通过双能X线骨密度仪每半年测定一次全身骨矿物质含量，密度和T分值，每年获取5d食物日记。重复测量结果表明，从基线值到第2年，骨矿物质含量，密度和T分数降低。基线和第2年之间的先验对比表明，补充铜和锌的下降最大。根据5天的食物日记，负面影响是由锌引起的，主要发生在锌摄入量> = 8.0 mg / d时。当锌摄入量＜8.0 mg / d时，补锌显然可以防止全身骨密度和T值显着下降。食物日记还表明，镁摄入量<237 mg / d，铜摄入量<0.9 mg / d和锌摄入量<8.0 mg / d与骨骼健康状况较差有关。研究结果表明，补充锌可能对通常锌摄入量＜8.0 mg / d的绝经后妇女的骨骼健康有益，但对摄入足够量锌的妇女不利。

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