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首页> 外文期刊>Biomaterials Science >The osteoblast and osteoclast responses to phosphonic acid containing poly(e-caprolactone) electrospun scaffolds
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The osteoblast and osteoclast responses to phosphonic acid containing poly(e-caprolactone) electrospun scaffolds

机译：成骨细胞和破骨细胞对含膦酸的聚（ε-己内酯）电纺丝支架的反应

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摘要

We describe a novel polymer containing phosphonic acid moieties which has been shown to increase the osteoblast response and decrease osteoclast activity. A 3D scaffold comprising of poly(e-caprolactone) (PCL) functionalised with poly(vinyl phosphonic acid-co-acrylic acid) (PVPA-AA) was fabricated using electrospinning. PVPA-AA is hypothesised to mimic the action of bisphosphonates, a group of drugs used to treat osteoporosis, and likely to affect bone turnover by increasing the activity of osteoblasts and reducing osteoclast activity. The expression of collagen type I, osteocalcin and alkaline phosphatase has been found to be significantly higher (p ≤ 0.001) on PCL/PVPA-AA scaffolds when compared to PCL and tissue culture plastic (TCP). In addition, after 21 days there was a significant increase (p ≤ 0.001) in mineralisation on PCL/PVPA-AA substrates. The PCL/PVPA-AA scaffold has been reported to significantly (p ≤ 0.001) decrease osteoclast viability, with comparable results to Alendronate, a commercially available bisphosphonate. For the first time, we describe a novel active synthetic bone graft substitute, which has been shown to increase osteoblast proliferation and matrix deposition as well as reducing the number of osteoclast cells by locally induced apoptosis. The combined affects of the novel PVPA-AA polymer on osteoblasts and osteoclasts may lead to active bone repair and healing.
机译：我们描述了一种新型的含有膦酸部分的聚合物，已显示可增加成骨细胞反应并降低破骨细胞活性。使用静电纺丝制造了一种3D支架，该支架包括由被聚（乙烯基膦酸-共丙烯酸）（PVPA-AA）官能化的聚（ε-己内酯）（PCL）。假设PVPA-AA可以模仿双膦酸盐（一种用于治疗骨质疏松症的药物）的作用，并可能通过增加成骨细胞活性和降低破骨细胞活性来影响骨转换。与PCL和组织培养塑料（TCP）相比，已发现PCL / PVPA-AA支架上的I型胶原蛋白，骨钙蛋白和碱性磷酸酶的表达明显更高（p≤0.001）。此外，在21天后，PCL / PVPA-AA基质上的矿化作用显着增加（p≤0.001）。据报道，PCL / PVPA-AA支架可显着（p≤0.001）降低破骨细胞活力，其结果可与市售双膦酸盐Alendronate媲美。首次，我们描述了一种新型的活性合成人工骨替代物，该替代物已显示出可通过局部诱导的凋亡增加成骨细胞增殖和基质沉积以及减少破骨细胞的数量。新型PVPA-AA聚合物对成骨细胞和破骨细胞的综合影响可能导致积极的骨修复和愈合。

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