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首页> 外文期刊>The British Journal of Nutrition >Associations between antioxidants and all-cause mortality among US adults with obstructive lung function
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Associations between antioxidants and all-cause mortality among US adults with obstructive lung function

机译：美国成年人阻塞性肺功能中抗氧化剂与全因死亡率之间的关联

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Chronic obstructive pulmonary disease is characterised by oxidative stress, but little is known about the associations between antioxidant status and all-cause mortality in adults with this disease. The objective of the present study was to examine the prospective associations between concentrations of alpha- and beta-carotene, beta-cryptoxanthin, lutein/zeaxanthin, lycopene, Se, vitamin C and alpha-tocopherol and all-cause mortality among US adults with obstructive lung function. Data collected from 1492 adults aged 20-79 years with obstructive lung function in the National Health and Nutrition Examination Survey III (1988-94) were used. Through 2006, 629 deaths were identified during a median follow-up period of 14 years. After adjustment for demographic variables, the concentrations of the following antioxidants modelled as continuous variables were found to be inversely associated with all-cause mortality among adults with obstructive lung function: alpha-carotene (P = 0.037); beta-carotene (P = 0.022); cryptoxanthin (P = 0.022); lutein/zeaxanthin (P = 0.004); total carotenoids (P = 0.001); vitamin C (P0.001). In maximally adjusted models, only the concentrations of lycopene (P = 0.013) and vitamin C (P = 0.046) were found to be significantly and inversely associated with all-cause mortality. No effect modification by sex was detected, but the association between lutein/zeaxanthin concentrations and all-cause mortality varied by smoking status (P-interaction = 0.048). The concentrations of lycopene and vitamin C were inversely associated with all-cause mortality in this cohort of adults with obstructive lung function. British Journal of Nutrition
机译：慢性阻塞性肺疾病的特征是氧化应激，但对于这种疾病的成年人，抗氧化剂状态与全因死亡率之间的关系知之甚少。本研究的目的是检查美国成人阻塞性肠梗阻患者中α-和β-胡萝卜素，β-隐黄质，叶黄素/玉米黄质，番茄红素，硒，维生素C和α-生育酚的浓度与全因死亡率之间的前瞻性关联肺功能。在国家健康和营养检查调查III（1988-94）中，使用了1492位年龄在20-79岁，患有阻塞性肺功能的成年人的数据。截至2006年，在14年的中位随访期内，确定了629例死亡。在调整了人口统计学变量后，发现以下建模为连续变量的抗氧化剂的浓度与阻塞性肺功能成人的全因死亡率成反比：α-胡萝卜素（P = 0.037）; β-胡萝卜素（P = 0.022）;隐黄质（P = 0.022）;叶黄素/玉米黄质（P = 0.004）;总类胡萝卜素（P = 0.001）;维生素C（P <0.001）。在经过最大调整的模型中，仅发现番茄红素（P = 0.013）和维生素C（P = 0.046）的浓度与全因死亡率显着且呈负相关。未检测到性别引起的效应改变，但叶黄素/玉米黄质浓度与全因死亡率之间的关联因吸烟状况而异（P相互作用= 0.048）。在患有阻塞性肺功能的成年人中，番茄红素和维生素C的浓度与全因死亡率成反比。英国营养杂志

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