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首页> 外文期刊>Biomaterials Science >Emerging antitumor applications of extracellularly reengineered polymeric nanocarriers
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Emerging antitumor applications of extracellularly reengineered polymeric nanocarriers

机译：细胞外再造聚合物纳米载体的新兴抗肿瘤应用

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摘要

Recently, polymeric nanocarriers with shielding surfaces, e.g., poly(ethylene glycol) and small molecules, have been widely applied in antitumor drug delivery mainly because of their stealth during blood circulation. However, the shielding shell greatly hinders the tumor penetration, drug release, and cell internalization of the nanocarriers, which leads to unsatisfactory therapeutic efficacy. To integrate the extended blood circulation time and the enhanced drug transmission in one platform, some extracellularly stimuli-mediated shell-sheddable polymeric nanocarriers have been exploited. The systems are stealthy and stable during blood circulation, and as soon as they reach tumor tissue, the shielding matrices are removed, which is triggered by extracellular endogenous stimuli (e.g., pH or enzymes) or exogenous excitations (e.g., light or voltage). This review mainly focuses on recent advances in the designs and emerging antitumor applications of extracellularly reengineered polymeric nanocarriers for directional drug delivery, as well as perspectives for future developments.
机译：近来，具有屏蔽表面的聚合物纳米载体，例如聚（乙二醇）和小分子，主要由于其在血液循环中的隐形性而被广泛用于抗肿瘤药物递送。然而，屏蔽壳极大地阻碍了肿瘤渗透，药物释放和纳米载体的细胞内在化，这导致了不令人满意的治疗效果。为了将延长的血液循环时间和增强的药物传递整合到一个平台中，已经开发了一些细胞外刺激介导的可脱壳的聚合物纳米载体。该系统在血液循环期间是隐身的并且稳定的，并且一旦到达肿瘤组织，就去除了屏蔽基质，这是由细胞外源性内源性刺激（例如，pH或酶）或外源性激发（例如，光或电压）触发的。这篇综述主要集中在细胞外再造的聚合物纳米载体在定向药物递送中的设计和新兴抗肿瘤应用方面的最新进展，以及未来的发展前景。

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